Results 51 to 60 of about 112,477 (323)

Inhibition of growth of hepatocellular carcinoma by co-delivery of anti-PD-1 antibody and sorafenib using biomimetic nano-platelets

BMC Cancer
Background Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments.
Xuanbo Da, Bangping Cao, Jiantao Mo, Yukai Xiang, Hai Hu, Chen Qiu, Cheng Zhang, Beining Lv, Honglei Zhang, Chuanqi He, Yulong Yang   +10 more
doaj   +1 more source

Erectile Dysfunction in Men With Gallbladder Stone Disease: A Nationwide Population-Based Study

American Journal of Men's Health, 2019
We assessed the risk of erectile dysfunction after the diagnosis of gallbladder stone disease. We identified 9,362 men aged ≥20 years diagnosed with gallbladder stone disease between 2000 and 2011 from Taiwan’s National Health Insurance Research Database
Chien-Hua Chen MD, Cheng-Li Lin MSc, Chia-Hung Kao MD   +2 more
doaj   +1 more source

The anatomical knowledge of Namibian school children

Anatomical Sciences Education, EarlyView.
Abstract The public has limited knowledge of key organs and anatomical structures. The lack of anatomical knowledge and understanding can hinder time to access healthcare, quality of care, and treatment outcomes. The current study investigated the anatomical knowledge among Namibian children by comparing 8 school grades—4 to 12, which covers children ...
Adam M. Taylor, Lojandrie Kirsten, Luigi Sedda, Quenton Wessels   +3 more
wiley   +1 more source

Intraoperative cholangiography and bile duct flushing in 47 dogs receiving laparoscopic cholecystectomy for benign gallbladder disease: A retrospective analysis [PDF]

, 2021
Hiroo Kanai, Tomomi Minamoto, Aya Nukaya, Motoki Kondo, Toshihide Aso, Ayako Fujii, Ken Hagiwara   +6 more
openalex   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Research progress in precision medicine for type 2 diabetes based on the GLP-1

Frontiers in Endocrinology
Diabetes Mellitus (DM) represents a global health crisis, currently affecting approximately 9% of the world’s population. Its prevalence continues to rise steadily, with a noticeable trend toward onset at younger ages.
Sangui Wang, Sangui Wang, Chenrong Yuan, Haifeng Wang, Xiyin Ye, Shun Ruan, Li Yi, Wanyong Yang, Zhi Wang, Ni Wang, Jiahao Li, Xiaohui Feng, Yun Li, Yu Tian, Quanlei Wang, Quanlei Wang   +15 more
doaj   +1 more source

Gamma Irradiation of Poly(lactide‐co‐glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Clinical islet transplantation has long been investigated as a potential cure for type 1 diabetes (T1D), yet standard intrahepatic delivery leaves islets prone to an instant blood‐mediated inflammatory response. Herein, we investigated the design of microporous poly(D,l‐lactide‐co‐glycolide) (PLG) scaffolds for extrahepatic islet ...
Jessica L. King, Christopher Spencer, Richard Youngblood, Kelly Crumley, Elizabeth Bealer, Peter D. Rios, Ira Joshi, Sofia Ghani, Douglas Isa, James J. McGarrigle, David Cook, Conor Locke, Adam Abraham, Andrea Clark, José Oberholzer, Lonnie D. Shea   +15 more
wiley   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis [PDF]

, 2006
Background. Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease.
Abdel-Wahab M, Abu Farsakh NA, Akdamar K, Bechi P, Benedikta Zündt, Burkhard Göke, Cabrol J, Cabrol J, Caldwell MT, Dieter Jüngst, Dixon MF, Dooley CP, Emmanouilidis A, Fahlke J, Fritz W. Spelsberg, Gad Elhak N, Gnatiuk NG, Hubens A, Hyvarinen H, Ihamaki T, Joachim Diebold, Johnsen R, Kellosalo J, Koch HK, Ladas SD, Lasse Kolligs, Lorusso D, Lorusso D, Lujan-Mompean JA, Mackie CR, Manifold DK, Niemela S, Panos Stathopoulos, Ritchie, Robles-Campos R, Svensson JO, Ure BM, Watson RG, Yavorski CC   +38 more
core   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source