Results 141 to 150 of about 38,667 (228)

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, Volume 117, Issue 8, Page 2085-2097, August 2026.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Acute Malignant Ascites Revealing Mucinous Adenocarcinoma of the Gallbladder: A Rare Case in a Recent Migrant. [PDF]

Cureus
Santos-Rivera JR, Jimenez Garcia JG, Izquierdo-Pretel G.   +2 more
europepmc   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, Volume 293, Issue 16, Page 4769-4788, August 2026.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

One of the Largest Reported Ciliated Foregut Cysts of the Gallbladder Mimicking a Gallbladder Diverticulum. [PDF]

Cureus
Nikolaus Y.
europepmc   +1 more source

Patient Expectations in High‐Risk Abdominal Surgery for Cancer

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Background Despite the central role of expectations in informed consent and surgical shared decision‐making, patient expectations frequently remain unelicited or underexplored and are often assumed rather than explicitly addressed. Objective To explore how patients form expectations about high‐risk abdominal surgery for cancer and how ...
Kimberly E. Kopecky, Jacquelyn E. F. Speer, Janet Julson, Alizeh Abbas, Olivia Monton, Fabian M. Johnston, J. Nicholas Odom   +6 more
wiley   +1 more source

Emerging Immune‐Based Therapeutic Strategies in Hepatocellular Carcinoma

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide despite recent advances in systemic therapy. The introduction of immune checkpoint inhibitors has substantially expanded treatment options for advanced disease; however, durable responses are observed only in a subset of patients.
Janine Kah, Werner Dammermann, Stefan Lueth   +2 more
wiley   +1 more source

Metastatic Malignant Neoplasm in the Gallbladder [PDF]

, 2020
openaire   +1 more source

Case Report: Successful conversion of gallbladder cancer with intrahepatic metastases using camrelizumab combined with gemcitabine and cisplatin. [PDF]

Front Immunol
Wang D, Li Y, Shi G, Wang W, Ma T, Mi C, Du Y, Wang S, Sheng X, Wang L, Xu X, Wang Y, Yang H.   +12 more
europepmc   +1 more source

Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta‐Analysis

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Objective This systematic review and meta‐analysis aimed to identify common life‐course body mass index (BMI) trajectories (childhood/adulthood to adulthood) and their impact on risk of cancer overall and cancer at different sites in adulthood. Methods Observational studies were identified that assessed the association of BMI trajectories with
Samira Behboudi‐Gandevani, Tommy Haugan, Nayla Cristina Do Vale Moreira, Ellen Christin Arntzen, Moira Strand Hutchinson, Melanie Nichols, Razieh Bidhendi‐Yarandi   +6 more
wiley   +1 more source

Recent survival trends in the most fatal cancers in the Nordic countries: gains in some but not in all. [PDF]

Acta Oncol
Hemminki K, Zitricky F, Försti A, Hemminki A.   +3 more
europepmc   +1 more source