Results 11 to 20 of about 33,551 (172)

Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

Cell Reports Medicine, 2020
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as ...
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto   +32 more
doaj   +1 more source

Use of Novel Antibiograms to Determine the Need for Earlier Susceptibility Testing and Administration for New β-Lactam/β-Lactamase Inhibitors in the United States

Antibiotics, 2022
Antimicrobial resistance is a global public health threat, and gram-negative bacteria, such as Enterobacterales and Pseudomonas aeruginosa, are particularly problematic with difficult-to-treat resistance phenotypes.
Kenneth P. Klinker, Levita K. Hidayat, Eric Wenzler, Joan-Miquel Balada-Llasat, Mary Motyl, C. Andrew DeRyke, Karri A. Bauer   +6 more
doaj   +1 more source

Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis

EBioMedicine, 2021
Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants.
Brian M. Maas, Jos Lommerse, Nele Plock, Radha A. Railkar, S.Y. Amy Cheung, Luzelena Caro, Jingxian Chen, Wen Liu, Ying Zhang, Qinlei Huang, Wei Gao, Li Qin, Jie Meng, Han Witjes, Emilie Schindler, Benjamin Guiastrennec, Francesco Bellanti, Daniel S. Spellman, Brad Roadcap, Mariya Kalinova, Juin Fok-Seang, Andrew P. Catchpole, Amy S. Espeseth, S. Aubrey Stoch, Eseng Lai, Kalpit A. Vora, Antonios O. Aliprantis, Jeffrey R. Sachs   +27 more
doaj   +1 more source

Long-Term Potentiation Is Increased in the CA1 Area of the Hippocampus of APPswe/ind CRND8 Mice

Neurobiology of Disease, 2002
The present study reports changes in synaptic function and plasticity [long-term potentiation (LTP)] in a recently developed mouse model of Alzheimer's disease (CRND8 line) harboring a double amyloid precursor protein mutation (APPswe/ind). In 9-week-old
Thierry Jolas, Xue-Song Zhang, Qi Zhang, Gwendolyn Wong, Robert Del Vecchio, Lisa Gold, Tony Priestley   +6 more
doaj   +1 more source

Energy harvesting from transverse galloping [PDF]

, 2010
Some elastic bluff bodies under the action of a fluid flow can experience transverse galloping and lose stability if the flow velocity exceeds a critical value.
A. Barrero-Gil, A. Sanz-Andres, Allen, Alonso, Barrero-Gil, Barrero-Gil, Blevins, Burton, G. Alonso, Liao, Murdock, Naudascher, Novak, Parkinson, Parkinson, Scanlan, Tang, Taylor, Zhu   +18 more
core   +2 more sources

A translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam

International Journal of Infectious Diseases, 2019
Objectives: Relebactam is a small molecule β-lactamase inhibitor under clinical investigation for use as a fixed-dose combination with imipenem/cilastatin.
Pratik Bhagunde, Zufei Zhang, Fred Racine, Donna Carr, Jin Wu, Katherine Young, Matthew L. Rizk   +6 more
doaj   +1 more source

Study on Adaptive Excitation System of Transmission Line Galloping Based on Electromagnetic Repulsive Mechanism

Shock and Vibration, 2021
Due to the uncontrollable weather conditions, it is difficult to carry out the controllable prototype test to study fatigue damage of transmission tower and armour clamp and the effect evaluation of antigalloping device under actual transmission line ...
Jiangjun Ruan, Li Zhang, Wei Cai, Daochun Huang, Jian Li, Zhihui Feng   +5 more
doaj   +1 more source

Transmission Line Galloping Prediction Based on GA-BP-SVM Combined Method

IEEE Access, 2021
The paper proposes a method to construct a model for transmission line galloping prediction using machine learning algorithms to address the transmission line galloping problem, which can result in transmission line loss and pose a greater risk to the ...
Ying Wei, Xuelian Gao
doaj   +1 more source

On the galloping instability of two-dimensional bodies having elliptical cross sections. [PDF]

, 2010
Galloping, also known as Den Hartog instability, is the large amplitude, low frequency oscillation of a structure in the direction transverse to the mean wind direction.
A. Sanz-Andrés, Alonso, Alonso, Alonso, Alonso, Barlow, Blevins, Blevins, Den Hartog, E. Valero, G. Alonso, Hémon, J. Meseguer, Meseguer, Naudascher, O’Meara, Schewe, Torenbeek   +17 more
core   +2 more sources

Experimental study on the galloping characteristics of single ice-coated transmission lines under oblique flows

Scientific Reports, 2023
Galloping of ice-coated transmission lines is occasionally observed under oblique wind directions. However, most current investigations on the galloping mechanisms are for flow perpendicular to the span of the transmission lines. In order to address this
Mingyang Gao, Zhaoqing Chen, Jin Su, Ning Su, Chuncheng Liu, Jinlong Zhang, Huiru Chen   +6 more
doaj   +1 more source