Results 101 to 110 of about 102,035 (308)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Length, Protein-Protein Interactions, and Complexity

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear.
Albert, Bateman, Bates, Bates, Boeckmann, Carlson, Daan Frenkel, Eisenhaber, Hasty, Hopkins, Jeong, Jeong, Lander, Mewes, Michael W. Deem, Mott, Prost, Rhines, Riddle, Steinmetz, Strausberg, Taison Tan, Uetz, Vishal Gupta, Watts, Waxman, Zhang, Zhang   +27 more
core   +1 more source

Gerbil: A Fast and Memory-Efficient $k$-mer Counter with GPU-Support [PDF]

, 2016
A basic task in bioinformatics is the counting of $k$-mers in genome strings. The $k$-mer counting problem is to build a histogram of all substrings of length $k$ in a given genome sequence.
Erbert, Marius, Müller-Hannemann, Matthias, Rechner, Steffen   +2 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Developing an agro-forestry system for production of a commercial organic chicken flock focusing on profits on a 'Triple bottom Line' [PDF]

, 2006
In most modern free-range poultry systems birds do not fully utilise the range provided. Knowledge of the ancestral history of the domestic chicken, and research observations suggests benefits of agro-forestry systems for chickens.
Aspray, C, O'Brian, J, Philips, L
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

MICROSATELLITE DIVERSITY IN BOS TAURUS, EQUUS CABALLUS AND GALLUS DOMESTICUS BREEDS REARED IN UKRAINE

Slovenian Veterinary Research
This study is dedicated to the comparative analysis of the main parameters of microsatellite variability in the populations of animals from different taxa (Bos taurus, Equus caballus, and Gallus domesticus) of different breeds, reared in Ukraine.
Andriy Shelyov, Roman O. Kulibaba, Kyrylo Kopylov, Kateryna Kopylova   +3 more
doaj   +1 more source

Sollicitos Galli dicamus amores : amor e amores nell’ecl. 10 di Virgilio

Pallas, 2017
Amor, a key-word in the last Virgilian eclogue, dedicated to the unhappy love of Gallus for Lycoris, has in the text a great importance, which deserves a careful analysis. The meaning of the term relates to the passion of Gallus for his beloved, but also
Paola Gagliardi
doaj   +1 more source

Biased amino acid composition in warm-blooded animals [PDF]

, 2009
Among eubacteria and archeabacteria, amino acid composition is correlated with habitat temperatures. In particular, species living at high temperatures have proteins enriched in the amino acids E-R-K and depleted in D-N-Q-T-S-H-A. Here, we show that this
Guang-Zhong Wang, Martin J. Lercher
core   +1 more source