Results 121 to 130 of about 102,033 (308)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Polymorphism of The Promote Region of Chicken Insulin like Growth Factor-1 and Association With Bone Abnormalitiesالتغ

مجلة مركز بحوث التقنيات الاحيائية, 2015
The insulin like growth factor-1(IGF-1) is important regulators in stimulating growth, protein synthesis, cell proliferation and differentiation in a variety of cell types.
Farah Thamer Abdullah
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

NEORILEYA ALBIPES (HYMENOPTERA: EURYTOMIDAE): PARASITOIDE DE HUEVOS DE ARILUS GALLUS (HEMIPTERA: REDUVIIDAE) EN FORTUNA, CHIRIQUÍ, PANAMÁ

Tecnociencia, 2022
La Reduviidae, incluye chinches depredadores como Arilus gallus (Stål, 1872), que contribuyen con el control natural de plagas en agroecosistemas productivos y con el balance ecológico en áreas protegidas.
Alonso Santos-Murga, Rubén Collantes González   +1 more
doaj  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Genomic origin and consequence of captive red junglefowl in zoological parks

BMC Genomics
Understanding the genetic status of captive animal populations is essential for their long-term conservation and effective management. In this study, we investigated the genetic origin, admixture patterns, and genomic health of red junglefowls (Gallus ...
Yuki Matsuda, Masaki Eda, Shuichi Ito, Tsuyoshi Shimmura   +3 more
doaj   +1 more source

Сезонные колебания фагоцитарной активности лейкоцитов Gallus domesticus [PDF]

, 2013
На материале клетки дрожжей и вегетативной клетки сенной палочки исследовалась сезонная активность элементов системы крови и функциональные возможности лейкоцитов Gallus ...
Адамова, В. В., Бородаева, Ж. А., Буковцова, И. С., Чернявских, С. Д.   +3 more
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