Results 121 to 130 of about 47,257 (306)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

open access: yesFEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller   +3 more
wiley   +1 more source

Cryopreservation of Indian Red Jungle Fowl (Gallus gallus murghi) spermatozoa: a first approach

open access: yes, 2017
Cryopreservation of Indian Red Jungle Fowl ([i]Gallus gallus murghi[/i]) spermatozoa: a first ...
Blesbois, Elisabeth   +6 more
core   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

open access: yesFEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li   +7 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

open access: yesFEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt   +2 more
wiley   +1 more source

Suprimento Arterial do Timo de Gallus gallus da Linhagem Peterson

open access: yes, 2008
Foram dissecados 30 exemplares de Gallus gallus, da linhagem Peterson, após injeção do sistema vascular arterial, via artéria isquiática direita, com Neoprene lá ...
Silva, Frederico Ozanan Carneiro e   +5 more
core   +1 more source

Expressão gênica de ApoA1 e ApoB em de frangos de corte de duas linhagens diferentes

open access: yesMedicina Veterinária, 2018
objetivo desse estudo foi avaliar a expressão gênica das apolipoproteínas A1 e B, bem como a relação entre elas no fígado de frangos de corte de duas linhagens, selecionada e não selecionada.
Angélica de Souza Khatlab   +5 more
doaj  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan   +5 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

Content of exDNA in rooster’s seminal plasma as a potential biomarker of sperm viability

open access: yesАграрная наука Евро-Северо-Востока
Searching biomarkers, that have an early prognostic trait and determinate functional status of male gametes Gallus Gallus is a promising direction for improving ejaculate’s quality reproductive characteristics.
A. A. Kurochkin   +2 more
doaj   +1 more source

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