Results 51 to 60 of about 5,752 (150)

Solid‐State NMR Reveals Reorganization of the Aspergillus fumigatus Cell Wall Due to a Host‐Defence Peptide

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Understanding the mode of action is critical to develop new antifungal drugs. Solid‐state NMR was used to study the reorganization of the Aspergillus fumigatus cell wall by a host‐defence peptide. We identified specific polysaccharides and amino acids that are affected by the peptide.
Ajit Kumar Bishoyi, Jacq van Neer, Salima Bahri, Sophie Lorenz, Hans de Cock, Marc Baldus   +5 more
wiley   +2 more sources

Identification of genetic variants associated with a wide spectrum of phenotypes clinically diagnosed as Sanfilippo and Morquio syndromes using whole genome sequencing

Frontiers in Genetics, 2023
Mucopolysaccharidoses (MPSs) are inherited lysosomal storage disorders (LSDs). MPSs are caused by excessive accumulation of mucopolysaccharides due to missing or deficiency of enzymes required for the degradation of specific macromolecules. MPS I-IV, MPS
Rutaba Gul, Rutaba Gul, Sabika Firasat, Mikkel Schubert, Asmat Ullah, Elionora Peña, Anne C. B. Thuesen, Annete P. Gjesing, Mulazim Hussain, Muhammad Tufail, Muhammad Saqib, Muhammad Saqib, Kiran Afshan, Torben Hansen   +13 more
doaj   +1 more source

Reduction of Charged Glycoconjugates in Tango2 KO Mouse Brain

Proteoglycan Research, Volume 4, Issue 1, January 2026.
ABSTRACT The transport and Golgi organization 2 (TANGO2) gene has been identified to cause a rare recessive genetic disorder known as TANGO2‐deficiency disorder (TDD). TDD is a multi‐systemic disorder that can affect different organs including the brain, heart, and muscles, presenting as recurrent metabolic crises, muscle weakness, and neurological ...
Edward S. X. Moh, Maike Stentenbach, Tim McCubbins, Nicolle H. Packer   +3 more
wiley   +1 more source

Polymorphisms in Tunisian patients with N-acetylgalactosamine-6-sulfate sulfatase gene deficiency: Implication in Morquio A disease

Diagnostic Pathology, 2011
Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes.
Chkioua Latifa, Khedhiri Souhir, Ferchichi Salima, Miled Abdelhedi, Laradi Sandrine   +4 more
doaj   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, Volume 2, Issue 4, Page 193-205, December 2025.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Importance of Long-Term Follow-Up in the Prognosis of Mucopolysaccharidosis IV-A: A Case Report from Southwestern of Colombia [PDF]

Journal of Inborn Errors of Metabolism and Screening
Mucopolysaccharidosis IV-A (MPS IV-A) is an autosomal recessive genetic disorder caused by a deficiency in the enzyme N-acetylgalactosamine-6-sulfatase, leading to the accumulation of chondroitin-6-sulfate (C6S) and keratan sulfate (KS).
Mariana Ardila Marín, Carlos Arturo Caicedo Toro, Jeyson Steven Rojas Banguero, José María Satizabal Soto, Daniela Arturo Terranova   +4 more
doaj   +1 more source

Depth‐dependent effects of short‐term whole‐soil warming on microbial necromass and plant lignin

Functional Ecology, Volume 39, Issue 11, Page 3269-3283, November 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The changes in the origins and storage of soil organic carbon (SOC) under a warming climate are closely related to SOC decomposition and the feedbacks to climate change.
Peng Tian, Xuechao Zhao, Thomas W. Crowther, Yakov Kuzyakov, Biao Zhu, Qingkui Wang   +5 more
wiley   +1 more source

Clinical, biochemical and genetic profiles of patients with mucopolysaccharidosis type IVA (Morquio A syndrome) in Malaysia: the first national natural history cohort study

Orphanet Journal of Rare Diseases, 2019
Background Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive lysosomal storage disease due to N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.
Huey Yin Leong, Nor Azimah Abdul Azize, Hui Bein Chew, Wee Teik Keng, Meow Keong Thong, Mohd Khairul Nizam Mohd Khalid, Liang Choo Hung, Norzila Mohamed Zainudin, Azura Ramlee, Muzhirah Aisha Md Haniffa, Yusnita Yakob, Lock Hock Ngu   +11 more
doaj   +1 more source

The GALNS p.P77R variant is a probable Gujarati-Indian founder mutation causing Mucopolysaccharidosis IVA syndrome

BMC Genomics, 2022
Background Mucopolysaccharidosis IVA (Morquio syndrome A, MPS IVA) is an autosomal recessive lysosomal storage disorder caused due to biallelic variants in the N-acetylgalactoseamine-6-sulfate sulfatase (GALNS) gene.
Harsh Sheth, Premal Naik, Maulin Shah, Riddhi Bhavsar, Aadhira Nair, Frenny Sheth, Jayesh Sheth   +6 more
doaj   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source