Results 181 to 190 of about 17,163 (306)

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin   +10 more
wiley   +1 more source

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

open access: yesCell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song   +15 more
wiley   +1 more source

Golden weapons and golden fetters: From the gold standard to the new geopolitics

open access: yesThe Economic History Review, EarlyView.
Abstract This paper explores the historical relationship between monetary regimes, security concerns, and geopolitical tensions, particularly focusing on the role of gold. Throughout history, monetary systems have been deeply intertwined with international state systems and security provisions.
Harold James
wiley   +1 more source

Realizing the unexpected: How cospecialization supports the serendipity journey in SMEs' digital transformation

open access: yesEuropean Management Review, EarlyView.
Abstract Although innovation is often portrayed as arising deterministically from deliberate strategy and calculated decisions, many significant breakthroughs emerge not from planning but serendipitously. Building on this insight, this paper bridges the literatures on dynamic capabilities and serendipity to examine how SMEs realize serendipitous value ...
Marco Balzano   +2 more
wiley   +1 more source

Integrating Merit and Equality to Address Gender Inequality at Work

open access: yesGender, Work &Organization, EarlyView.
ABSTRACT Although the extant literature provides a comprehensive account of workplace gender inequalities, the mechanisms that produce inequalities, and the underlying assumptions and principles of those mechanisms, remain opaque. The concept of “merit,” although morally persuasive and ubiquitous in organizational contexts, is a significant point of ...
Paula McDonald   +2 more
wiley   +1 more source

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