Results 71 to 80 of about 6,738 (290)

Legacy gambling harms: What are they and how long do they last? [PDF]

, 2022
Matthew Rockloff, Matthew Browne, Alex Russell, Nerilee Hing, Tess Armstrong, Nancy Greer   +5 more
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Visualizing and Quantifying Impact with Mechanochromic Sensing Paints Based on Self‐Assembled Polydiacetylene‐Silk Core‐Shell Vesicles

Advanced Science, EarlyView.
Tracking physical impacts is important in many fields. Self‐assembled microparticles made from polydiacetylene and silk fibroin that change color from blue to red when hit can provide an alternative approach to traditional mechanical transducers, quantitatively visualizing impact with responses ranging from <100 to 770 N.
Marco Lo Presti, Giulia Guidetti, Elisabetta Ruggeri, Terri Lyne Carrington, Fiorenzo G. Omenetto   +4 more
wiley   +1 more source

The identification of Australian low-risk gambling limits: A comparison of gambling-related harm measures [PDF]

, 2021
Nicki A. Dowling, Christopher Greenwood, Stephanie Merkouris, George J. Youssef, Matthew Browne, Matthew Rockloff, Paul Myers   +6 more
openalex   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

National burden of gambling in Japan: an estimation from an online-based cross-sectional investigation and national epidemiological survey

BMC Public Health
Background Gambling is a popular leisure activity in many countries, often expected to boost regional economies. Nevertheless, its negative impacts remain a significant concern.
Chiyoung Hwang, Ryuhei So, Nozomu Hashimoto, Toshiaki Baba, Sachio Matsushita, Matthew Browne, Toshiya Murai, Norio Watanabe, Naoko Takiguchi   +8 more
doaj   +1 more source

Review: Insight on Porous Carbon Positive Electrode for Sodium‐Ion Capacitors: Interplay Between Synthesis, Properties, and Performance

Advanced Science, EarlyView.
Sodium ion capacitor (SIC) is currently constrained by the low discharge capacity of commercial activated carbon as positive electrode material. This review provides a holistic summary of research efforts on alternative porous carbon materials for SIC. Image created by the authors with www.biorender.com.
Ademola Adeniji, Adrian Beda, Camélia Matei Ghimbeu   +2 more
wiley   +1 more source

Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture

Advanced Science, EarlyView.
Inhaled NCM particles undergo lysosomal degradation, releasing complex ion mixtures that induce systemic impact. The impact is determined by a critical balance between antagonistic Ni‐Co interactions and synergistic Mn effects. To capture these complexities in risk assessment, we develop an IAI model, ensuring a more accurate quantitative risk ...
Ze Zhang, Gan Miao, Xueyu Zhang, Zhao Shu, Dawei Lu, Yujie Song, Shanfa Yu, Qian Liu, Yang Song, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Ultrahigh‐Linear Bio‐Inspired Janus Elastomeric Strain Sensor with High Sensitivity and Stretchability via Surface Wrinkle Engineering

Advanced Science, EarlyView.
A bio‐inspired Micro‐wrinkled Janus elastomeric flexible strain sensor mimicking wrinkled‐leaf viburnum is developed. Endowed with a synergistic sensing mechanism including wrinkle‐guided microcracks, modulus‐gradient‐driven strain division, and a parallel conductive circuit, it achieves ultra‐high linearity, sensitivity, wide strain range, and ...
Jing Lin, Ye Li, Simi Yu, Xing Cheng, Longxin Qian, Yufei Chen, Womin Li, Zhipeng Yang, Yinlei Lin, Dechao Hu, Jianyi Luo, Lan Liu   +11 more
wiley   +1 more source