Results 81 to 90 of about 1,340,355 (353)

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

A Grey-Box Approach to Automated Mechanism Design [PDF]

, 2010
Auctions play an important role in electronic commerce, and have been used to solve problems in distributed computing. Automated approaches to designing effective auction mechanisms are helpful in reducing the burden of traditional game theoretic ...
Cai, Kai, Niu, Jinzhong, Parsons, Simon
core   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

A game based approach to improve traders' decision-making [PDF]

, 2015
Purpose: The development of a game based approach to improving the decision-making capabilities of financial traders through attention to improving the regulation of emotions during trading. Design/methodology/approach: The project used a design-based
Adam, Marc, Clough, Gill, Conole, Grainne, Fenton-O'Creevy, Mark, Gaved, Mark, Lindley, Craig, Lins, Jeffrey Todd, Peffer, Gilbert, Scanlon, Eileen, Smidts, Ale   +9 more
core  

‘More like an Arcade’ – The Limitations of Playable Games in Museum Exhibitions

Museum & Society, 2019
This study investigated the relationship between playable, interactive games on original hardware and the representation of game culture using the case of the exhibition Game On 2.0, often considered to be the largest exhibition of digital games in the ...
Patrick Prax, Lina Eklund, Björn Sjöblom   +2 more
doaj   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

Advanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani, Aditi Singh, Behnam Ashrafi   +2 more
wiley   +1 more source

Dundee Discussion Papers in Economics 111:Do debtor-favored contracts necessarily benefit the debtor? [PDF]

, 2000
We consider a case of security design, where the optimal contract depends on the nature of the future renegotiations game. It is shown that giving the bargaining power to the debtor in the renegotiations game may not always work in his ...
Mishra, Ajit
core  

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

People overlook subtractive changes differently depending on age, culture, and task

Scientific Reports
Previous work has explored transformative strategies that adds or removes components to change an original structure or state, and showed that adults tend to search for additive solutions far more often than subtractive ones.
Joshua Juvrud, Laurence Myers, Pär Nyström   +2 more
doaj   +1 more source