Results 51 to 60 of about 148,868 (311)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Stochastic Maximum Principle for Markov Chains of Mean-Field Type
Games, 2018 We derive sufficient and necessary optimality conditions in terms of a stochastic maximum principle (SMP) for controls associated with cost functionals of mean-field type, under dynamics driven by a class of Markov chains of mean-field type which are ...
Salah Eddine Choutri, Tembine Hamidou
doaj +1 more source
Pattern Formation and Tropical Geometry
Frontiers in Physics, 2020 Sandpile models exhibit fascinating pattern structures: patches, characterized by quadratic functions, and line-shaped patterns (also called solitons, webs, or linear defects).
Nikita Kalinin, Nikita Kalinin
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Game Theory and Evolution [PDF]
IEEE Intelligent Systems, 2013 Key concepts are described from the area now known as evolutionary game theory, while also introducing some important applications of these concepts.
Steve Phelps, Michael J. Wooldridge
openaire +2 more sources
The International Conference on Game Theory and Management [PDF]
, 2021 This note overviews the Game Theory and Management conferences that have been held annually at Saint Petersburg State University since ...
Sedakov, Artem
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
EntropyIn recent years, several global events have severely disrupted economies and social structures, undermining confidence in the resilience of modern societies.
Florian Schunck +3 more
doaj +1 more source