Results 221 to 230 of about 7,163,180 (311)

From Artificial to Embodied and Physical Intelligence in Smart Manufacturing

open access: yesAdvanced Science, EarlyView.
Smart manufacturing is reframed through complementary artificial, embodied, and physical intelligence, spanning computational reasoning, perception‐action coupling, and material‐level adaptation. Their integration across design, fabrication, operation, and maintenance reveals how intelligence can be co‐designed across algorithms, embodied agents, and ...
Kang Wang   +9 more
wiley   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

open access: yesAdvanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler   +4 more
wiley   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

open access: yesAdvanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao   +10 more
wiley   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

open access: yesAdvanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li   +13 more
wiley   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

open access: yesAdvanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu   +12 more
wiley   +1 more source

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