Results 61 to 70 of about 6,511,477 (348)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

The Game Semantics of Game Theory

open access: yes, 2023
We use a reformulation of compositional game theory to reunite game theory with game semantics, by viewing an open game as the System and its choice of contexts as the Environment. Specifically, the system is jointly controlled by $n \geq 0$ noncooperative players, each independently optimising a real-valued payoff.
openaire   +2 more sources

Instructional Design and Facilitation for Multigenerational Online Learning in Higher Education—Baby Boomers, Generation X, Millennials, and Generation Z

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Nontraditional students represent a substantial number and significant percentage of students in higher education. While these adult learners have similarities, they also span 50+ years with generational differences. At the same time, online learning is on the rise, offering opportunities and challenges for nontraditional students and those ...
Brittany Hyden, Catherine A. Cherrstrom
wiley   +1 more source

A Dynamic Network Model of Societal Complexity and Resilience Inspired by Tainter’s Theory of Collapse

open access: yesEntropy
In recent years, several global events have severely disrupted economies and social structures, undermining confidence in the resilience of modern societies.
Florian Schunck   +3 more
doaj   +1 more source

Game Theory and Emotions [PDF]

open access: yesRationality and Society, 1997
To illustrate the rational-choice modeling of emotions, a game-theoretic model of frustration, in which players respond in anger to their lack of control, is developed. Of the 57 distinct 2 × 2 strict ordinal conflict games, 12 turn out to be `frustration games', in four of which `threat power', based on the theory of moves, offers relief to the ...
openaire   +3 more sources

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

open access: yesInternational Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam   +2 more
wiley   +1 more source

The fiducial lower confidence limits of reliability for standby system based on zero-failure data(基于无失效数据贮备系统可靠性的fiducial置信限)

open access: yesZhejiang Daxue xuebao. Lixue ban, 2010
研究元件具有无失效试验数据的贮备系统可靠性的评定问题.由无失效试验数据下元件可靠性置信下限的定义,得到元件分布参数的fiducial分布.并以此为出发点,对基于指数寿命型元件的无失效成败型试验数据、贮备系统的切换开关的成败型试验数据,在开关的成功概率分别为已知和未知的情形下,导出了由指数寿命型元件组成的贮备系统可靠性的fiducial置信下限的计算公式,并给出了算例.
JIANGRen-bin(蒋仁斌)   +1 more
doaj   +1 more source

Game Theory and Game Mechanics Design [PDF]

open access: yesSHS Web of Conferences
This paper focuses on the significance of game balance in games and explores the application of game theory concepts for designing and analyzing balanced gameplay.
Pi Jiasheng
doaj   +1 more source

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

open access: yesAdvanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe   +4 more
wiley   +1 more source

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