Results 111 to 120 of about 3,581 (172)

Drug Repurposing in Pre‐Eclampsia: Maternal Pharmacokinetic and Pharmacodynamic Considerations for Clinical Trial Design

Clinical Pharmacology &Therapeutics, EarlyView.
Pre‐eclampsia is a hypertensive disorder of pregnancy affecting 3–8% of pregnancies worldwide, with no disease‐modifying therapy currently available. Drug repurposing offers a promising strategy, yet no candidate has been validated to date. Pregnancy‐associated physiological changes alter drug pharmacokinetics (PK), and pre‐eclampsia itself may further
Cassius M. Phogole, Engi Abdel‐Hady Algharably, Eric H. Decloedt, Catherine Anne Cluver, Veshni Pillay‐Fuentes Lorente   +4 more
wiley   +1 more source

Case Report: Jet lag and travel fatigue effects on performance in a world-class paralympic shot-putter after eastward long-haul transmeridian travel. [PDF]

Front Sports Act Living
Garcia-Carrillo E, Thapa RK, Hermosilla-Palma F, Alarcón-Rivera M, Farías-Valenzuela C, Azócar-Gallardo J, Yáñez-Sepúlveda R, Olivares-Arancibia J, Castillo-Paredes A, Calleja-González J, Judge LW, Fuentes-Barría H, Mello JB.   +12 more
europepmc   +1 more source

Environment Friendly Sustainable End‐Of‐Life Solutions for Plastic Components in Indian Automotive Industries

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Growing concerns about the environmental and social consequences of plastics around the world, manufacturing industries are associated with business are focusing on sustainable end‐of‐life options‐based solutions which aim at increasing the product life cycle.
Sivakumar Kirupanandan, Deepak Mathivathanan, Jayakrishna Kandasamy, Michele Mosca   +3 more
wiley   +1 more source

Improved preservation of hearts from old donors during static cold storage by the senomorphic agent ruxolitinib. [PDF]

Front Transplant
Saemann L, Kozar B, Pohl S, Hoffmeister A, Wernstedt L, Gong Y, Simm A, Szabó G.   +7 more
europepmc   +1 more source

Fracture evolution of a thick soft protection layer and the water inrush mechanism in overburden under longwall mining

Deep Underground Science and Engineering, EarlyView.
Through shear–tensile creep tests and viscoelastic modeling, the fracture evolution of thick soft protective layers is clarified. Results show thickness‐dependent rheological failure modes that govern four types of roof water inrush, providing a mechanism‐based framework for hazard prediction and control. Abstract In the Jurassic coal‐bearing strata of
Mengnan Liu, Wei Qiao, Xianggang Cheng, Xiangsheng Meng, Peichao Feng   +4 more
wiley   +1 more source

The intervention effect of structured martial arts games on behavioral impairments and motor functions in children with autism spectrum disorder. [PDF]

Front Psychol
Fu X, Shi P.
europepmc   +1 more source

Optimization of artificial neural network models using genetic algorithm for accurate estimation of water saturation

Deep Underground Science and Engineering, EarlyView.
A comprehensive comparative study of five artificial neural network (ANN) architectures (convolutional neural network [CNN], recurrent neural network, feedforward neural network, multi‐layer perceptron, radial basis function network) was conducted for water saturation prediction in petroleum reservoirs.
Ali Akbari, Ali Ranjbar
wiley   +1 more source

Comparative assessment of artificial intelligence chatbots' performance in responding to healthcare professionals' and caregivers' questions about Dravet syndrome

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence chatbots have been a game changer in healthcare, providing immediate, round‐the‐clock assistance. However, their accuracy across specific medical domains remains under‐evaluated. Dravet syndrome remains one of the most challenging epileptic encephalopathies, with new data continuously emerging in the ...
Joana Jesus‐Ribeiro, Eugenia Roza, Bárbara Oliveiros, Joana Barbosa Melo, Mar Carreño   +4 more
wiley   +1 more source

Natural language processing‐based emotion and usage analysis of an AI‐powered chatbot for epilepsy support

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence (AI)‐powered chatbots are increasingly used for patient education and mental health support, yet their effectiveness in epilepsy care remains underexplored. This study examines text‐based interactions between users and EpiloBot, an epilepsy‐focused chatbot, to understand conversational patterns and emotional ...
Keiichi Watanuki, Ryoya Oba, Naoki Nozawa, Tomoki Ishihara, Koko Oga, Takayuki Iwayama, Takafumi Shiganami, Sayaka Kobayashi, Hironori Kuga, Haruo Yoshimasu, Izumi Kuramochi   +10 more
wiley   +1 more source