Results 41 to 50 of about 166,025,159 (298)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Indonesian Journal of Physical Education and Sport Science, 2023 Study purpose. Biomechanics is a branch of science that studies the forms and types of human movement based on mechanical principles in a sport that can minimize the occurrence of sports injuries. The purpose of this study was to see the effectiveness of
Muhammad Suhairi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Designing serious games to advance climate change adaptation
Environmental Research CommunicationsThe escalating impact of climate change necessitates innovative strategies to enhance public understanding and action. This research delves into the potential of serious games as transformative tools for climate change education and adaptation.
Emily Nabong, Aaron Opdyke
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Endogenous Timing of Moves in Bertrand-Edgeworth Triopolies [PDF]
, 2012 We determine the endogenous order of moves in which the firms set their prices in the framework of a capacity-constrained Bertrand-Edgeworth triopoly. A three-period timing game that determines the period in which the firms announce their prices precedes
Tasnádi, Attila
core +2 more sources
International Journal of Financial Studies, 2019 An attendance model is specified for the Canadian Hockey League (CHL), the top level of junior hockey in Canada with some teams located in the United States.
Rodney Paul +2 more
doaj +1 more source
The Running Performance Decrement in Elite Hurling
Applied Sciences, 2020 Since the COVID-19 restrictions, hurling games have been played in four quarters instead of two halves. This study described the decrement in running performance between quarters in elite hurling.
Damien Young +3 more
doaj +1 more source
BMC Sports Science, Medicine and Rehabilitation, 2022 Aim This study tested the effects of two training programs (one program based on extreme sided-games of 1v1 vs. one program based on the medium-sided game of 5v5) on the physical fitness adaptations of youth soccer players.
Piotr Makar +6 more
doaj +1 more source