Results 41 to 50 of about 20,463 (308)
BMC Sports Science, Medicine and Rehabilitation, 2022 Aim This study tested the effects of two training programs (one program based on extreme sided-games of 1v1 vs. one program based on the medium-sided game of 5v5) on the physical fitness adaptations of youth soccer players.
Piotr Makar +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Epidemiology of Shoulder Instability in the National Football League
Orthopaedic Journal of Sports Medicine, 2021 Background: Shoulder instability is a common and potentially debilitating injury among collision sport athletes that can lead to long-term damage of the glenohumeral joint.
Matthew J.J. Anderson MD +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Designing serious games to advance climate change adaptation
Environmental Research CommunicationsThe escalating impact of climate change necessitates innovative strategies to enhance public understanding and action. This research delves into the potential of serious games as transformative tools for climate change education and adaptation.
Emily Nabong, Aaron Opdyke
doaj +1 more source
Sleep in Habitual Adult Video Gamers: A Systematic Review
Frontiers in Neuroscience, 2021 Video gaming is a popular, globally recognized phenomenon, played recreationally or competitively as esports. Gaming is a typically sedentary nighttime activity; therefore, the potential to impact sleep and health is high.
Chadley Kemp +7 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Teaching a Robot Bimanual Hand-Clapping Games via Wrist-Worn IMUs
Frontiers in Robotics and AI, 2018 Colleagues often shake hands in greeting, friends connect through high fives, and children around the world rejoice in hand-clapping games. As robots become more common in everyday human life, they will have the opportunity to join in these social ...
Naomi T. Fitter +3 more
doaj +1 more source
On timed alternating simulation for concurrent timed games [PDF]
Acta Informatica, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bozzelli, Laura +2 more
openaire +6 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source