Results 131 to 140 of about 249,931 (264)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

An Advanced High‐Performance Ultrafast Ammonium‐Ion Aqueous Battery Based on Dual‐Metal Redox Open Framework Molecular Magnet

Advanced Science, EarlyView.
The Prussian Blue Analogue molecular magnet KMnFeHCF is demonstrated as a high‐performance cathode for ultra‐fast aqueous ammonium‐ion batteries. A full cell using KMnFeHCF and graphite delivers ~71 mAh g−1 at 1.25 A g−1 and ~51 mAh g−1 at 2.2 A g−1, retaining 50% capacity after 1850 cycles. Its scalability, cycling stability, and low cost offer strong
Nilasha Maiti, Pramod Bhatt, Manoj K Sharma, Sher Singh Meena, Mayuresh D Mukadam, Soumen Samanta   +5 more
wiley   +1 more source

Author Correction: Evidence of an upper ionospheric electric field perturbation correlated with a gamma ray burst. [PDF]

Nat Commun, 2023
Piersanti M, Ubertini P, Battiston R, Bazzano A, D'Angelo G, Rodi JG, Diego P, Zeren Z, Ammendola R, Badoni D, Bartocci S, Beolè S, Bertello I, Burger WJ, Campana D, Cicone A, Cipollone P, Coli S, Conti L, Contin A, Cristoforetti M, De Angelis F, De Donato C, De Santis C, Di Luca A, Fiorenza E, Follega FM, Gebbia G, Iuppa R, Lega A, Lolli M, Martino B, Martucci M, Masciantonio G, Mergè M, Mese M, Morbidini A, Neubüser C, Nozzoli F, Nuccilli F, Oliva A, Osteria G, Palma F, Palmonari F, Panico B, Papini E, Parmentier A, Perciballi S, Perfetto F, Perinelli A, Picozza P, Pozzato M, Rebustini G, Recchiuti D, Ricci E, Ricci M, Ricciarini SB, Russi A, Sahnoun Z, Savino U, Scotti V, Shen X, Sotgiu A, Sparvoli R, Tofani S, Vertolli N, Vilona V, Vitale V, Zannoni U, Zoffoli S, Zuccon P.   +70 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Probing Thermal Electrons in Gamma-Ray Burst Afterglows

The Astrophysical Journal
Particle-in-cell simulations have unveiled that shock-accelerated electrons do not follow a pure power-law distribution, but have an additional low-energy “thermal” part, which owns a considerable portion of the total energy of the electrons ...
Hao-Xuan Gao, Jin-Jun Geng, Tian-Rui Sun, Liang Li, Yong-Feng Huang, Xue-Feng Wu   +5 more
doaj   +1 more source

SHORT SOFT Г-RAY BURST SPECTRAL EVOLUTION

Odessa Astronomical Publications, 2017
Short  Soft  Gamma-Ray  bursts  are  considered  as  neutron  star  crust  magnetoemission.  Statistics of temporal burst properties are shown to display univesal features.
V. N. Kondratyev
doaj   +1 more source

A pH‐Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury

Advanced Science, EarlyView.
A biomimetic nanoplatform (CeAst@MK) is engineered for precise therapy of acute kidney injury by integrating cerium‐based antioxidation, natural flavonoid astragalin, and macrophage membrane camouflage. Featuring kidney‐targeted and pH‐responsive release, CeAst@MK scavenges ROS, suppresses inflammation, and restores renal function via modulation of ...
Shichao Zhang, Yuhan Xie, Longchao Zhang, Yuanjiong Qi, Quan Liao, Chenglong Xu, Shushuai Yang, Haiwen Zhou, Qidan Tan, Shiyong Qi   +9 more
wiley   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Gamma-Ray Burst Pulse Structures and Emission Mechanisms

The Astrophysical Journal
The prompt phase X-ray and gamma-ray light curves of gamma-ray bursts (GRBs) exhibit erratic and complex behaviors, often with multiple pulses. The temporal shape of the individual pulses is often modeled as “fast rise exponential decay” (FRED). Here, we
A Gowri, A. Pe’er, F. Ryde, H. Dereli-Bégué   +3 more
doaj   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source