Results 301 to 310 of about 257,446 (367)

14. Discogenic Low Back Pain

open access: yesPain Practice, Volume 25, Issue 7, September 2025.
ABSTRACT Introduction Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher ...
Wouter K. M. van Os   +6 more
wiley   +1 more source

Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low‐Temperature Photothermal Effects

open access: yesAngewandte Chemie, Volume 137, Issue 32, August 4, 2025.
This study innovatively develops a multifunctional, multienzyme‐active nanoplatform (FeCP@PDA‐GOx), aimed at overcoming the limitations of traditional cancer therapies and achieving precise, efficient, and long‐lasting melanoma treatment. By integrating starvation therapy, CDT, mPTT, and immunotherapy, FeCP@PDA‐GOx generates a multidimensional ...
Qihang Ding   +6 more
wiley   +2 more sources

High‐permeability cellulose nanocrystals mediate systemic zinc redistribution through nsLTP2‐dependent immune potentiation in plants

open access: yesPlant Biotechnology Journal, Volume 23, Issue 9, Page 4175-4190, September 2025.
Summary Zinc (Zn2+) is an essential micronutrient that regulates plant growth, immunity and antiviral defence mechanisms. However, its limited bioavailability often necessitates excessive application, resulting in inefficiencies in production and environmental stress.
Jing Wang   +10 more
wiley   +1 more source

Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery

open access: yesThe FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi   +2 more
wiley   +1 more source

Multi-messenger gravitational lensing. [PDF]

open access: yesPhilos Trans A Math Phys Eng Sci
Smith GP   +40 more
europepmc   +1 more source

Time‐Resolved Leader Spectra of Downward Terrestrial Gamma‐Ray Flashes Observed at the Telescope Array Surface Detector

open access: yesJournal of Geophysical Research: Atmospheres, Volume 130, Issue 16, 28 August 2025.
Abstract The first time‐resolved leader spectra associated with a downward Terrestrial Gamma‐ray Flash (TGF) observed by the Telescope Array Surface Detector (TASD) were recently reported by Kieu et al. (2024, https://doi.org/10.1029/2024JD041720). Building on that study, this paper presents the time‐resolved leader spectra of two additional downward ...
N. Kieu   +143 more
wiley   +1 more source

Electrochemical loading enhances deuterium fusion rates in a metal target. [PDF]

open access: yesNature
Chen KY   +14 more
europepmc   +1 more source

<title>Coded-aperture x-ray/gamma-ray telescope for arc-minute localization of gamma-ray bursts</title>

open access: green, 1999
M. L. Cherry   +14 more
openalex   +2 more sources

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