Results 71 to 80 of about 15,460 (204)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He   +8 more
wiley   +1 more source

Modellers clash over gamma ray bursters

open access: yesPhysics World, 1992
One slide comfortably held all the facts about cosmic gamma ray bursters that a panel of four theorists could agree on during the Compton Gamma Ray symposium held at Washington University, St Louis, in October (where Arthur H Compton did his Nobel-prize scattering). The most striking fact is that we are at the centre of the source distribution; and yet
openaire   +3 more sources

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun   +8 more
wiley   +1 more source

Ultraviolet Light Curves of Supernovae with Swift Uvot

open access: yes, 2008
We present ultravioliet (UV) observations of supernovae (SNe) obtained with the UltraViolet/Optical Telescope (UVOT) on board the Swift spacecraft. This is the largest sample of UV light curves from any single instrument and covers all major SN types and
Brown   +59 more
core   +1 more source

Gamma-ray burster counterparts - Archival data

open access: yesThe Astrophysical Journal, 1990
This paper reports on the results of a search for optical transient images associated with gamma-ray bursters based on the collection of archival photographs at the Harvard College Observatory. This study searched through over 32,000 plates showing 16 gamma-ray burst error regions.
openaire   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

open access: yesAdvanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu   +4 more
wiley   +1 more source

GRIPS and the Perspective of Next-generation Gamma-ray Surveys

open access: yes, 2011
GRIPS is one example of next generation telescopes proposed for astronomy the energy range between hard X-ray mirror instruments such as NuStar and the Fermi telescope.
Diehl, Roland
core   +1 more source

Relativistic electron-positron beams in gamma-ray bursters

open access: yesThe Astrophysical Journal, 1993
Beams of relativistic electrons and/or positrons leaving the surface of a strongly magnetized neutron star may give rise to gamma-ray bursts. The beams could be accelerated by strong, magnetically aligned electric fields that are produced by oscillations of the stellar surface. Here we investigate the particle acceleration in these electric fields, the
I. A. Smith, Richard I. Epstein
openaire   +1 more source

NAKED SINGULARITIES AS CANDIDATES FOR GAMMA-RAY BURSTERS [PDF]

open access: yesInternational Journal of Modern Physics D, 1994
Naked singularities appear naturally in dynamically evolving solutions of Einstein equations involving gravitational collapse of radiation, dust, and perfect fluids provided the rate of accretion is less than a critical value. We propose that the gamma-ray bursters (GRBs) are examples of these naked singularity solutions.
SANDIP K. CHAKRABARTI, PANKAJ S. JOSHI
openaire   +1 more source

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