Search for the shortest variability at gamma rays in flat-spectrum radio quasars [PDF]
, 2011 We report about the search for short-term variability in the high-energy gamma-ray energy band of three flat-spectrum radio quasars (3C 454.3, 3C 273, PKS B1222+216), whose flux at E > 100 MeV exceeded the value of 10^-5 ph cm^-2 s^-1 for at least one ...
L. Foschini +4 more
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Gamma-Rays from Intergalactic Shocks [PDF]
, 2002 Structure formation in the intergalactic medium (IGM) produces large-scale, collisionless shock waves, where electrons can accelerate to highly relativistic energies.
Hernquist, Lars +4 more
core +4 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Time lag between prompt optical emission and gamma-rays in GRBs
, 2006 The prompt optical emission contemporaneous with the $\gamma$-rays from $\gamma$-ray bursts (GRBs) carries important information on the central engine and explosion mechanism. We study the time lag between prompt optical emission and $\gamma$-rays in GRB
Akerlof +12 more
core +1 more source
Cosmogenic gamma-rays and the composition of cosmic rays [PDF]
, 2011 We discuss the prospects of detecting the sources of ultrahigh energy (UHE) cosmic ray (CR) nuclei via their emission of cosmogenic {gamma} rays in the GeV to TeV energy range.
M. Ahlers, J. Salvado
semanticscholar +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Cosmic-Ray Events as Background in Imaging Atmospheric Cherenkov Telescopes
, 2007 The dominant background for observations of gamma-rays in the energy region above 50 GeV with Imaging Atmospheric Cherenkov telescopes are cosmic-ray events.
Aharonian +14 more
core +1 more source
Distributions of secondary muons at sea level from cosmic gamma rays below 10 TeV [PDF]
, 2001 The FLUKA Monte Carlo program is used to predict the distributions of the muons which originate from primary cosmic gamma rays and reach sea level. The main result is the angular distribution of muons produced by vertical gamma rays which is necessary to
A Fassò +14 more
core +2 more sources