Results 41 to 50 of about 1,118,400 (283)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Quantitative comparison of presumed-number-density and quadrature moment methods for the parameterisation of drop sedimentation

Meteorologische Zeitschrift, 2014
In numerical weather prediction models, parameterisations are used as an alternative to spectral modelling. One type of parameterisations are the so-called methods of moments.
Corinna Ziemer, Gary Jasor, Ulrike Wacker, Klaus D. Beheng, Wolfgang Polifke   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Machine Learning Approach-Based Gamma Distribution for Brain Tumor Detection and Data Sample Imbalance Analysis

IEEE Access, 2019
Recently, artificial intelligence applications in magnetic resonance imaging have been applied in several clinical studies. The analysis of brain tumors without human intervention is considered a significant area of research because the extracted brain ...
Gunasekaran Manogaran, P. Mohamed Shakeel, Azza S. Hassanein, Priyan Malarvizhi Kumar, Gokulnath Chandra Babu   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Poly-Weighted Exponentiated Gamma Distribution with Application

Journal of Statistical Theory and Applications (JSTA), 2020
This paper proposes a weighting of the exponentiated gamma distribution with a polynomial function called the poly-weighted exponentiated gamma distribution (PWEGD).
E. B. Nkemnole, E. M. Ikegwu
doaj   +1 more source

Effect of Probability Distribution of the Response Variable in Optimal Experimental Design with Applications in Medicine

Mathematics, 2021
In optimal experimental design theory it is usually assumed that the response variable follows a normal distribution with constant variance. However, some works assume other probability distributions based on additional information or practitioner’s ...
Sergio Pozuelo-Campos, Víctor Casero-Alonso, Mariano Amo-Salas   +2 more
doaj   +1 more source

The Gamma Distribution [PDF]

Significance, 2019
AbstractJohn Dagpunar introduces a probability distribution to model real-valued positive measurements, such as time spent queuing for a taxi or waiting for a hospital ...
openaire   +2 more sources

Distribution Of Wealth In A Network Model Of The Economy

, 2012
We show, analytically and numerically, that wealth distribution in the Bouchaud-M\'ezard network model of the economy is described by a three-parameter generalized inverse gamma distribution.
Holden, John G., Ma, Tao, Serota, R. A.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source