Results 91 to 100 of about 1,392,060 (284)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Calculator of some special mathematical functions [PDF]

open access: yesSerbian Journal of Electrical Engineering
This paper presents the implementation of a calculator of certain special mathematical functions in the form of an efficient web application with a simple and intuitive GUI (graphical user interface).
Lazić Sara, Iričanin Bratislav
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

On the role of three functions in the Riemann literatures

open access: yes, 2019
In Riemann's paper and Nachlass on the zeta function, $\pi^{-\frac{s}{2}}\Gamma(\frac{s}{2})\zeta(s)$ has three different functional expressions, of which $$\pi^{-\frac{s}{2}}\Gamma(\frac{s}{2})\zeta(s)=2\Re[\pi^{-\frac{s}{2}}\Gamma(\frac{s}{2})f(s ...
Feng, Nianrong, Wang, Yongzheng
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Monotonic nature of the Gamma function

open access: yesJournal of Inequalities and Applications
This study begins by examining the monotonic behavior of the function ln Γ ( x + 1 ) / ( ln ( x 2 + 6 ) − ln ( x + 6 ) ) $\ln \Gamma (x+1)/\left (\ln \left (x^{2}+6\right )-\ln (x+6)\right )$ on the interval x ∈ ( − 1 , 1 ) $x\in (-1,1)$ , supported by ...
Teodor Bulboacă, Hanaa M. Zayed
doaj   +1 more source

On the Application of a Hypergeometric Identity to Generate Generalized Hypergeometric Reduction Formulas

open access: yesAxioms
We systematically exploit a new generalized hypergeometric identity to obtain new hypergeometric summation formulas. As a consistency test, alternative proofs for some special cases are also provided.
Juan Luis González-Santander
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

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