Results 191 to 200 of about 4,044 (208)

Engineering baculo- and lentiviral vectors for enhanced and targeted gene delivery (Geeninsiirron tehostaminen ja kohdentaminen pintamuokatuilla bakulo- ja lentiviruksilla) [PDF]

Kaikkonen, Minna
core  

Longitudinal analysis of lentiviral and retroviral chimeric antigen receptors' integration sites reveals distinct clonal evolutionary patterns. [PDF]

Br J Haematol
Guiraud V, Denis JA, Benhafoun G, Ablin E, Sayon S, Souchet L, Azar N, Grenier A, Metz C, Legrand R, Marcelin AG, Choquet S, Calvez V, Todesco E.   +13 more
europepmc   +1 more source

Silencing and Variegation of Gammaretrovirus and Lentivirus Vectors

Human Gene Therapy, 2005
Retrovirus vectors integrate into the genome, providing stable gene transfer, but integration contributes in part to transcriptional silencing that compromises long-term expression. In the case of gammaretrovirus vectors based on murine leukemia virus, many integration events are completely silenced in undifferentiated stem cells and in transgenic mice.
James H. Ellis
semanticscholar   +5 more sources

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Prevalence of human xenotropic murine leukemia virus‐related gammaretrovirus (XMRV) in dutch prostate cancer patients

The Prostate, 2011
AbstractBACKGROUNDThe occurrence of the retrovirus xenotropic murine leukemia virus (MLV)‐related virus (XMRV) has been reported in prostate tissue of patients with prostate cancer (PrCa). Considering the potential great medical and social relevance of this discovery, we investigated whether this finding could be confirmed in an independent group of ...
G. Verhaegh, A. D. de Jong, F. Smit, Sander A. Jannink, W. Melchers, J. Schalken   +5 more
semanticscholar   +4 more sources

Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer

Journal of Clinical Virology, 2008
We previously identified a novel exogenous gammaretrovirus (xenotropic murine leukemia virus-related gammaretrovirus (XMRV)) using a pan-viral microarray. XMRV is the first MLV-related virus found in human infection. Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the ...
Nicole, Fischer, Olaf, Hellwinkel, Claudia, Schulz, Felix K H, Chun, Hartwig, Huland, Martin, Aepfelbacher, Thorsten, Schlomm   +6 more
openaire   +2 more sources

Partial correction of murine β-thalassemia with a gammaretrovirus vector for human γ-globin

Blood Cells, Molecules, and Diseases, 2006
Several studies have demonstrated that recombinant lentivirus vectors containing extended globin gene expression cassettes and regulatory elements can ameliorate the pathogenic sequela in murine models of beta-thalassemia and sickle cell disease. Similarly promising results have not yet been obtained with recombinant gammaretrovirus vectors.
Tamon Nishino, Julie Tubb, David W. Emery   +2 more
openalex   +3 more sources

Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy

Cancer Gene Therapy, 2009
Y-S Tsai, A-L Shiau, Yih‐Fung Chen, H-T. Tsai, T. S. Tzai, Chao‐Liang Wu   +5 more
openalex   +2 more sources

Efficient Gene Marking with a Clinical Gammaretrovirus Vector Expressing MGMTP140K in Baboons and Macaques

Blood, 2008
Abstract Using gene therapy to protect hematopoietic stem cells (HSC) from alkylating agents used in the treatment of malignant disease is an attractive strategy to alleviate prolonged neutropenia and thrombocytopenia that is dose-limiting. Both adult and pediatric patients with glioblastomas urgently need improved therapeutic strategies
Brian C. Beard, Megan L. Welsh, Grant D. Trobridge, Hans‐Peter Kiem   +3 more
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Integration Bias of Gammaretrovirus Vectors following Transduction and Growth of Primary Mouse Hematopoietic Progenitor Cells with and without Selection

Molecular Therapy, 2006
The recent recognition that recombinant retrovirus vectors can induce oncogenic transformation has stimulated much interest in the pattern of vector integration sites. We report here on the integration pattern of a gammaretrovirus reporter vector following transduction and ex vivo culture of primary mouse bone marrow progenitor cells in the absence and
Mari Aker, Julie Tubb, Daniel G. Miller, George Stamatoyannopoulos, David W. Emery   +4 more
openalex   +3 more sources

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV)

Virus Genes, 2012
A xenotropic murine leukemia virus-related virus (XMRV) has been reported to be an emerging pathogen associated with prostate cancer (PC) and chronic fatigue syndrome (CFS). However, recent studies have demonstrated that XMRV is a laboratory-derived virus resulting from genetic recombination between two mouse viral genomes during serial xenograft ...
Xiaochu Ma, Shiying Zhou, Meili Wei, Yanxia Chen, Jiaqiang Li, Weiliang Xiong, Shibo Jiang, Chungen Pan   +7 more
openalex   +3 more sources