Results 211 to 220 of about 19,645 (254)

Properties of Antisera to Ganglioside GM1 and Asialo GM1

The Journal of Immunology, 1974
Abstract The object of this study is to prepare antisera to purified glycosphingolipids for immunocytochemical studies. Rabbits were immunized with ganglioside GM1 complexed either to methylated BSA or to a glycoprotein isolated from human erythrocytes, and to asialo GM1 complexed to the erythrocyte glycoprotein.
M, Naiki, D M, Marcus, R, Ledeen
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Reduction of cerebral edema with GM1 ganglioside

Journal of Neuroscience Research, 1984
AbstractAdministration of exogenous gangliosides has been reported to accelerate neurite outgrowth in vitro, and to enhance peripheral nerve regeneration and central nervous system recovery subsequent to damage. After injury, facilitation of CNS recovery with GM1 ganglioside treatment has been postulated to be due to enhanced neuronal regeneration ...
S E, Karpiak, S P, Mahadik
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Structural and dynamic views of GM1 ganglioside

Glycoconjugate Journal, 2015
The ganglioside GM1 mediates various physiological and pathological processes mainly through the formation of GM1 clusters on cell surfaces. Therefore, detailed characterization of conformational properties of the glycan moiety of GM1 and the structures and interactions of this glycosphingolipid in membrane environments is necessary for better ...
Maho, Yagi-Utsumi, Koichi, Kato
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Total synthesis of gangliosides GM1 and GM2

Carbohydrate Research, 1986
Synthese de (O-glycosyl N-tetracosanoyl) sphingosines.
M, Sugimoto, M, Numata, K, Koike, Y, Nakahara, T, Ogawa   +4 more
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Organization of ganglioside GM1 in phosphatidylcholine bilayers

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1985
Molecules of the ganglioside GM1 are randomly distributed in liquid-crystalline 1-palmitoyl-2-oleoyl phosphatidylcholine bilayers. This conclusion is based on a freeze-etch electron microscopic study using ferritin-conjugated cholera toxin and cholera toxin alone as ganglioside labels.
T E, Thompson, M, Allietta, R E, Brown, M L, Johnson, T W, Tillack   +4 more
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Conformational study of asialo-GM1 (GA1) ganglioside

Biopolymers, 1997
In order to investigate the significance of preferred conformations of the saccharide for the steric orientation and recognition of glycosphingolipids at the membrane surface, the conformational free energy calculations were carried out on the asialo-GM1 [GA1; beta-D-Gal (1-->3) beta-D-GalNac(1-->4) beta-D-Gal(1-->4) beta-D-Glc-O-ceramide) using a new ...
H J, Park, G J, Jhon, S J, Han, Y K, Kang   +3 more
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GM1 ganglioside and Alzheimer’s disease

Glycoconjugate Journal, 2015
Assembly and deposition of amyloid ß-protein (Aß) is an invariable and fundamental event in the pathological process of Alzheimer's disease (AD). To decipher the AD pathogenesis and also to develop disease-modifying drugs for AD, clarification of the molecular mechanism underlying the Aß assembly into amyloid fibrils in the brain has been a crucial ...
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Trifluoromethyl Derivatization of the Ganglioside, GM1

Synthesis, 2010
A practical synthetic route to a terminally trifluoromethylatedanalogue of the ganglioside G M1 is described. It is basedon regioselective chemical manipulation of naturally occurring G M1 isolatedfrom bovine brain. Lyso-G M1 obtained by simple chemical transformationwas then simply acylated with the NHS ester of trifluorostearicacid. The ability
Krishna Kumar, Zhao Liu
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GM1 Ganglioside: Past Studies and Future Potential

Molecular Neurobiology, 2015
Gangliosides (sialic acid-containing glycosphingolipids) are abundant in neurons of all animal species and play important roles in many cell physiological processes, including differentiation, memory control, cell signaling, neuronal protection, neuronal recovery, and apoptosis.
M. Aureli, L. Mauri, M.G. Ciampa, A. Prinetti, G. Toffano, C. Secchieri, S. Sonnino   +6 more
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Mimicking Gangliosides by Design: Mimics of GM1 Headgroup

Neurochemical Research, 2002
Detailed knowledge of the three-dimensional structure of ganglioside headgroups has allowed the successful design of structural and functional mimics of ganglioside GMI oligosaccharide. Our recent work in this area is reviewed in this paper.
A. Bernardi, D. Arosio, S. Sonnino
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