Results 221 to 230 of about 19,645 (254)

Is Ganglioside GM1 Effective in the Treatment of Stroke?

Drugs & Aging, 1991
Nine double-blind, placebo-controlled clinical trials involving 784 patients with nonhaemorrhagic stroke have been reviewed to investigate the clinical efficacy of ganglioside GM1 in this disorder. The evaluated data show a statistically significant, but transient, acceleration in recovery from neurological deficits in 63% of all GM1-treated patients ...
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Synthesis of a Pseudo Tetrasaccharide Mimic of Ganglioside GM1

European Journal of Organic Chemistry, 1999
The pseudo tetrasaccharide 2 was designed to mimic ganglioside GM1, the membrane receptor of both the cholera toxin and of the heat-labile toxin of E. coli. Compound 2 retains the Gal and Neu5Ac recognition determinant of GM1 and uses as the scaffold element a new, conformationally restricted cyclohexanediol (DCCHD 3), with the same relative and ...
A. Bernardi, G. Boschin, A. Checchia, M. Lattanzio, L. Manzoni, D. Potenza, C. Scolastico   +6 more
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Cytoprotective effects of liposomal ganglioside GM1

Journal of Liposome Research
Gangliosides, glycosphingolipids with one or more N-acetyl-neuraminic acid groups, play essential roles in various cellular and biological processes, among them are cell signaling, neuronal development, cell-cell recognition and the modulation of immune response.
Volkmar, Weissig, Medha D, Joshi, Raymond Q, Migrino   +2 more
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Radioiodinated ganglioside GM1: a potential tool for the investigation of ganglioside function

Pharmacological Research Communications, 1985
Ganglioside GM1 was labeled with 125I either directly or after conjugation to tyramine. Direct iodination of the sphingosine chain resulted in a compound which dehalogenated rapidly both in vitro and in vivo. The binding of the 125I[GM1-tyramine] conjugate to neuronal membranes in vitro was similar to that reported for 3H-GM1.
M, Zalutsky, P, Magistretti, P, Gallagher, R, Ghidoni   +3 more
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Comparison of the 13C-n.m.r. spectra of gangliosides GM1 with those of GM1-oligosaccharide and asialo-GM1

Carbohydrate Research, 1983
The 13C-n.m.r. spectra of asialo-GM1 and GM1-oligosaccharide are completely assigned and compared to those previously found for intact GM1 and for the series GM4, GM3, GM2, GM1, GD1a, GD1b, and GT1b. Removal of the ceramide residue from GM1 liberated a free, reducing aldehyde group, which was reflected in a doubling of the 13C-n.m.r. signals assignable
L O, Sillerud, R K, Yu
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Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxin

Biochemistry, 1992
The ability of Fuc-GM1 ganglioside to mimic the receptor function of GM1 for cholera toxin (CT) has been investigated. For this purpose, rat glioma C6 cultured cells were enriched with Fuc-GM1 and the responsiveness to CT was compared with that of cells enriched with GM1 ganglioside.
MASSERINI, MASSIMO ERNESTO, Freire, E, PALESTINI, PAOLA NOVERINA ADA, Calappi, E, Tettamanti, G.   +4 more
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Effect of ganglioside (GM1) on memory in senescent rats

Neurobiology of Aging, 1996
Monosialoganglioside GM1 (GM1) has been found to alleviate genetic and lesion-induced memory deficits. The purpose of this study was to investigate the effects of 7-day treatment with GM1 (50 mg/kg IP) on acquisition and retention performance of senescent rats in a passive avoidance situation.
Silva, Regina Helena da UNIFESP, Felicio, Luciano Freitas, Nasello, Antonia Gladys, Vital, Maria Aparecida Barbato Frazao UNIFESP, Frussa-Filho, Roberto UNIFESP   +4 more
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Acute motor neuropathy with antibodies to GM1 ganglioside

Journal of Neurology, 1991
We describe a 52-year-old man who had an acute-onset purely motor neuropathy fulfilling the diagnostic criteria for the Guillain-Barré syndrome, in whom virtually complete spontaneous recovery occurred by 1 year, and in whom high titres of polyclonal serum antibody to GM1, GD1b, asialo-GM1 and lacto-N-tetraose were detected.
N A, Gregson, D, Jones, P K, Thomas, H J, Willison   +3 more
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Antibodies to ganglioside GM1 in patients with Alzheimer's disease

Neuroscience Letters, 1988
Gangliosides are thought to have a role in neuronal development and regeneration while anti-ganglioside antibodies have been shown to impair these processes. In the present work we examined whether the neuronal degeneration in Alzheimer's disease is associated with the presence of anti-ganglioside antibodies.
J, Chapman, B A, Sela, E, Wertman, D M, Michaelson   +3 more
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Chorea-acanthocytosis with polyclonal antibodies to ganglioside GM1

Journal of the Neurological Sciences, 1997
A patient with chorea-acanthocytosis presenting with axonal neuropathy showed an elevation in IgM polyclonal antibodies to the GM1 ganglioside, which were estimated by enzyme-linked immunosorbent assay and complement-mediated liposome immune lysis assay (LILA). This is the first demonstration of such antibodies in chorea-acanthocytosis.
M, Hirayama, T, Hamano, M, Shiratori, T, Mutoh, T, Kumano, T, Aita, M, Kuriyama   +6 more
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