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Gangliosides as Immunomodulators
2007Gangliosides are glycosphingolipids expressed at the outer leaflet of the plasmatic membrane of cells from vertebrate organisms. These molecules exert diverse biological functions including modulation of the immune system responses. Aberrant expression of gangliosides has been demonstrated on malignant cells. Besides expression on tumor cell membranes,
Galina V. Shurin +2 more
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Ganglioside Storage Diseases [PDF]
New England Journal of Medicine, 1971 For almost 100 years Tay-Sachs disease was the only ganglioside storage disease known. A second inborn error of ganglioside metabolism, generalized gangliosidosis, was discovered in 1965.13,35 Three additional ganglioside storage diseases have recently been uncovered,4,3,52,66,74 bringing the total to five.36 Of these, three involve storage of ...
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Calorimetric studies on various gangliosides and ganglioside-lipid interactions
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1982Differential scanning calorimetry was used to investigate the thermotropic behaviour of various gangliosides differing in size and in the net negative charge. It was found that the number and the position of the negative charges in the headgroup region influence strongly the phase transition profiles.
Ben-Ami Sela +2 more
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Gangliosides and autoimmune diabetes
Diabetes / Metabolism Reviews, 1997Gangliosides are sialic acid-containing glycolipids which are formed by a hydrophobic portion, the ceramide, and a hydrophilic part, i.e. the oligosaccharide chain. First described in neural tissue, several studies have shown that gangliosides are almost ubiquitous molecules expressed in all vertebrate tissues.
MISASI, Roberta +6 more
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Lipid and glycolipid mediators are important messengers of the adaptive responses to stress, including apoptosis. In mammalian cells, the intracellular accumulation of ganglioside GD3, an acidic glycosphingolipid, contributes to mitochondrial damage, a crucial event during the apoptopic program. GD3 is a minor ganglioside in most normal tissues.
MALISAN, FLORENCE, TESTI, ROBERTO
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Lipid and glycolipid mediators are important messengers of the adaptive responses to stress, including apoptosis. In mammalian cells, the intracellular accumulation of ganglioside GD3, an acidic glycosphingolipid, contributes to mitochondrial damage, a crucial event during the apoptopic program. GD3 is a minor ganglioside in most normal tissues.
MALISAN, FLORENCE, TESTI, ROBERTO
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Gangliosides and Tumorigenesis
1981Glycolipids are molecules whose roles as membrane or cell surface receptors that might contribute to the regulation or control of tumorigenesis are just beginning to be understood. Glycolipid changes are consistent features of the complex patterns of glycoconjugate alterations contributing to cancer (Hakomori 1975; Richardson et al.
K. E. Creek +2 more
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A ganglioside spin label: Ganglioside head group interactions
Biochemical and Biophysical Research Communications, 1977Abstract A general procedure has been developed for covalent attachment of a nitroxide spin label in the head group region of gangliosides. Gangliosides so labeled and incorporated into lipid bilayer vesicles give a sharp, 3-line spectrum characteristic of a highly mobile structure.
Chris W.M. Grant, Frances J. Sharom
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2019
Gangliosides comprise a varied family of glycosphingolipid structures bearing one or more sialic acid residues. They are found in all mammalian tissues but are most abundant in the brain, where they represent the quantitatively major class of sialoglycans.
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Gangliosides comprise a varied family of glycosphingolipid structures bearing one or more sialic acid residues. They are found in all mammalian tissues but are most abundant in the brain, where they represent the quantitatively major class of sialoglycans.
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Biochemistry, 1984
Ultraviolet difference absorption spectra of cholera toxin and its B protomer produced by the oligosaccharide moiety of the monosialoganglioside GM1 were measured as a function of the oligosaccharide concentration. In the presence of oligosaccharide, the spectrum is characterized by three peaks at 282, 288, and 292 nm.
D'Agnolo G +4 more
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Ultraviolet difference absorption spectra of cholera toxin and its B protomer produced by the oligosaccharide moiety of the monosialoganglioside GM1 were measured as a function of the oligosaccharide concentration. In the presence of oligosaccharide, the spectrum is characterized by three peaks at 282, 288, and 292 nm.
D'Agnolo G +4 more
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GANGLIOSIDES IN THE NERVOUS SYSTEM
Neurochemistry International, 1983Gangliosides, sialic acid-containing glycosphingolipids, are embedded in neural plasma membranes to provide cell surface recognition sites with negative charges. Exogenous ligands such as bacterial toxins, hormones, growth factors, antibodies, viruses, and interferons bind to specific gangliosides to induce sequential activations of cellular ...
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