Results 31 to 40 of about 588 (179)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Uncertainty and self‐efficacy in parents of a child with congenital cataract—New implications for clinical practice

Nursing Open, 2019
Aim The aim was an in‐depth exploration of uncertainty and self‐efficacy among parents of a child with congenital cataract by means of two theoretical frameworks to re‐design family care.
Jenny Gyllén, Gunilla Magnusson, Anna Forsberg   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Road to Sustainable Smart Cities: Modeling Residents’ Acceptance and Expectations of Smart, Connected, and Fully Autonomous Vehicles Employing SEM, NCA, and Machine Learning

IEEE Access
Smart, Connected, and Fully Autonomous Vehicles (SC-FAVs) are increasingly linked to sustainable smart-city mobility, yet research has focused mainly on what drives acceptance rather than how acceptance relates to residents’ quality-of-life ...
Wecka Imam Yudhistyra, Chalita Srinuan, Nuttawut Rojniruttikul   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Comprehensive User Acceptance Evaluation Framework of Intelligent Driving Based on Subjective and Objective Integration—From the Perspective of Value Engineering

Systems
Intelligent driving technology is expected to reshape urban transportation, but its promotion is hindered by user acceptance challenges and diverse technical routes. This study proposes a comprehensive user acceptance evaluation framework for intelligent
Wang Zhang, Fuquan Zhao, Zongwei Liu, Haokun Song, Guangyu Zhu   +4 more
doaj   +1 more source

Review of Roundabout Capacity Based on Gap Acceptance

Journal of Advanced Transportation, 2019
Circulating vehicles have priority at modern roundabouts. Entrance vehicles can enter the roundabout when there is a time gap larger than the critical gap; otherwise, the vehicles need to wait until there is a large enough gap.
Ruijun Guo, Leilei Liu, Wanxiang Wang
doaj   +1 more source

Comparison of Procedures to Estimate Critical Headways at Roundabouts

Promet (Zagreb), 2013
The capacity analysis of roundabouts in Portugal is mostly done using the UK regression method. Due to its empirical and non-explanatory nature, this method has some limitations, particularly for studying innovative layouts, which has recently motivated ...
António Luís Pimentel Vasconcelos, Álvaro Jorge Maia Seco, Ana Maria César Bastos Silva   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source