Results 231 to 240 of about 4,461,069 (318)

Evaluation of the DAMSUN-HF trial: the role of an artificial intelligence stethoscope in detecting reduced ejection fraction in patients living in a low-resource region. [PDF]

Heart Fail Rev
Abramov D, Cheema BS, Keramida K, Hosseini K, Fudim M, Minhas AMK.   +5 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids. [PDF]

J Ethnopharmacol
Dutta R, Holvoet H, Marney L, Cabey K, Neff C, Brandes M, Zweig J, Martinez J, Choi J, McClure C, Alam MN, Yang L, Poeck B, Stevens JF, Kretzschmar D, Gray NE, Strauss R, Maier CS, Soumyanath A.   +18 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Substance use disorder prevalence in Sierra Leone: a sex-disaggregated analysis using the World Health Organization equity data. [PDF]

Subst Abuse Treat Prev Policy
Osborne A.
europepmc   +1 more source

A photographic gap fraction method for estimating leaf area of isolated trees: Assessment with 3D digitized plants.

Tree Physiology, 2006
J. Phattaralerphong, J. Phattaralerphong, J. Sathornkich, Hervé Sinoquet   +3 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Structural, morphological, and optical properties of SiC/PVP nanocomposite materials by changing the SiC concentration in PVP. [PDF]

RSC Adv
Gahramanli L, Jafarov M, Muradov M, Mahmudova T, Alakbarova S, Addayeva Z, Gulahmadov O, Mammadov V, Khankishiyeva R, Vacacela Gomez C, Trapalis C, Yevdokymenko V, Dmytro K, Tene T.   +13 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Future projections of European maize yields using AquaCrop with an adaptive growing season.

Eur J Agron
Busschaert L, Deketelaere V, Thiery W, Raes D, De Lannoy GJM.   +4 more
europepmc   +1 more source