Results 191 to 200 of about 1,332,853 (314)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Complementary role of humanitarian civil society organisations in bridging gaps in immunisation programming in conflict and crisis-affected settings: the REACH Project experience. [PDF]

BMJ Glob Health
Olorunsaiye CZ, Ho LS, Malalu PK, Chatterjee G, Mutanda P, Dechasa Demissie S, Farrenkopf BA, Miller L.   +7 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Using Collection Development Policy to Address Critical Collection Gaps [Video]

Recording of a presentation that discusses two new policy approaches that were initiated in the spring of 2021 to address critical collection gaps in the Library of Congress' web archiving program. This recording originated from the IIPC General Assembly
Joshi, Rashi
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Using Collection Development Policy to Address Critical Collection Gaps [Presentation]

This presentation discusses two new policy approaches that were initiated in the spring of 2021 to address critical collection gaps in the Library of Congress' web archiving program. Presentation for the IIPC General Assembly and Web Archiving Conference
Joshi, Rashi
core  

Consistently longer silent gaps in autistic speaker pairs across three conversational contexts. [PDF]

Sci Rep
Wehrle S, Spaniol M, Vogeley K, Grice M.
europepmc   +1 more source

Filling in the Gaps [PDF]

The American Journal of Sports Medicine, 2008
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring the availability and content of vaccinology courses across the globe: A scoping review. [PDF]

Hum Vaccin Immunother
Nyasulu PS, Tamuzi JL, Iwu-Jaja C, Tiwari R, Sakala DY, Wiysonge CS, English R, Chikte U.   +7 more
europepmc   +1 more source