Results 141 to 150 of about 3,035,782 (282)

Exploring Ligand Effects in the Selective Catalytic Dehydrogenative Borylation of Alkynes with Aluminum

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Proper selection of a modified guanidinato ligand allows for the selective catalytic dehydroborylation of terminal alkynes by an air‐stable aluminum complex. A plausible reaction pathway is suggested based on DFT studies, where the auxiliary substituent of the guanidinato ligand actively participates in the activation of the σ CH bond.
Carlos Ginés   +6 more
wiley   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo   +17 more
wiley   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

open access: yesAdvanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li   +12 more
wiley   +1 more source

NG2-Glia Heterogeneity Across Cortical Layers. [PDF]

open access: yesGlia
Barriola S   +5 more
europepmc   +1 more source

Unveiling Dipolar Interaction‐Driven Magnetic Field Inhomogeneities in T2 MRI Contrast Agents

open access: yesAdvanced Science, EarlyView.
In this study, chemically designed nanoscale‐distance‐tuned based on silica‐coated iron oxide nanoparticles are used to investigate how dipolar interactions affect magnetic resonance imaging (MRI) contrast. By varying shell thickness, researchers modulated dipolar interactions and observed an exponential increase in transverse relaxivity (r2) that ...
Pelayo García‐Acevedo   +6 more
wiley   +1 more source

Dysphagia Aortica: An Uncommon and Potentially Life-Threatening Condition

open access: yesGE: Portuguese Journal of Gastroenterology, 2022
Francisco Vara-Luiz   +5 more
doaj   +1 more source

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