Results 11 to 20 of about 13,854 (246)

Prognosis of recurrent bacterial vaginosis based on longitudinal changes in abundance of Lactobacillus and specific species of Gardnerella

PLoS ONE, 2021
Refractory responses to standard-of-care oral metronidazole among recurrent bacterial vaginosis (BV) patients is not rare, and recurrence within a year is common. A better understanding of the bacterial determinants of these outcomes is essential.
Robert A Akins
exaly   +3 more sources

Gardnerella Exposures Alter Bladder Gene Expression and Augment Uropathogenic Escherichia coli Urinary Tract Infection in Mice

Frontiers in Cellular and Infection Microbiology, 2022
The anaerobic actinobacterium Gardnerella was first isolated from the bladder by suprapubic aspiration more than 50 years ago. Since then, Gardnerella has been increasingly recognized as a common and often abundant member of the female urinary microbiome
Nicole M. Gilbert, Valerie P. O’Brien, Chevaughn Waller, Ekatherina Batourina, Cathy Lee Mendelsohn, Amanda L. Lewis   +5 more
doaj   +2 more sources

Antibiotic resistance and pathogenicity assessment of various Gardnerella sp. strains in local China

Frontiers in Microbiology, 2022
Gardnerella overgrowth is the primary cause of bacterial vaginosis (BV), a common vaginal infection with incidences as high as 23–29% worldwide. Here, we studied the pathogenicity, drug resistance, and prevalence of varying Gardnerella spp.
Kundi Zhang, Mengyao Lu, Xiaoxuan Zhu, Kun Wang, Xuemei Jie, Tan Li, Hongjie Dong, Rongguo Li, Fengyu Zhang, Lichuan Gu   +9 more
doaj   +2 more sources

Gardnerella subgroup dominant microbiomes are associated with divergent cervicovaginal immune responses in a longitudinal cohort of Kenyan women

Frontiers in Immunology, 2023
Most cervicovaginal microbiome-immunology studies to date have relied on 16S rDNA microbial profiling which does not resolve the molecular subgroups of Gardnerella, believed to be central to the pathogenesis of bacterial vaginosis (BV) and subsequent ...
Elinor Shvartsman, Elinor Shvartsman, Elinor Shvartsman, Catia T. Perciani, Meika E. I. Richmond, Meika E. I. Richmond, Justen N. H. Russell, Justen N. H. Russell, Riley H. Tough, Riley H. Tough, Sarah J. Vancuren, Janet E. Hill, KAVI-ICR, Walter Jaoko, Lyle R. McKinnon, Lyle R. McKinnon, Lyle R. McKinnon, Paul A. Sandstrom, Paul A. Sandstrom, Kelly S. MacDonald, Kelly S. MacDonald, Kelly S. MacDonald, Kelly S. MacDonald   +22 more
doaj   +2 more sources

Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo

Pathogens, 2021
Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome and a characteristic biofilm formed on the vaginal epithelium, which is initiated and dominated by Gardnerella bacteria, and is frequently refractory to antibiotic treatment ...
Christine Landlinger, Lenka Tisakova, Vera Oberbauer, Timo Schwebs, Abbas Muhammad, Agnieszka Latka, Leen Van Simaey, Mario Vaneechoutte, Alexander Guschin, Gregory Resch, Sonja Swidsinski, Alexander Swidsinski, Lorenzo Corsini   +12 more
doaj   +2 more sources

Gardnerella diversity and ecology in pregnancy and preterm birth

mSystems, 2023
The vaginal microbiome has been linked to negative health outcomes including preterm birth. Specific taxa, including Gardnerella spp., have been identified as risk factors for these conditions.
Hanna L. Berman, Daniela S. Aliaga Goltsman, Megan Anderson, David A. Relman, Benjamin J. Callahan   +4 more
doaj   +2 more sources

Metabolic Network Models of the Gardnerella Pangenome Identify Key Interactions with the Vaginal Environment

mSystems, 2023
Gardnerella is the primary pathogenic bacterial genus present in the polymicrobial condition known as bacterial vaginosis (BV). Despite BV’s high prevalence and associated chronic and acute women’s health impacts, the Gardnerella pangenome is largely ...
Lillian R. Dillard, Emma M. Glass, Amanda L. Lewis, Krystal Thomas-White, Jason A. Papin   +4 more
doaj   +2 more sources

Dequalinium Chloride Effectively Disrupts Bacterial Vaginosis (BV) Gardnerella spp. Biofilms

Pathogens, 2021
Bacterial vaginosis (BV) is the most frequent vaginal infection worldwide. It is caused by the overgrowth of anaerobic vaginal pathogens such as Gardnerella spp.
Carlos Gaspar, Joana Rolo, Nuno Cerca, Rita Palmeira-de-Oliveira, José Martinez-de-Oliveira, Ana Palmeira-de-Oliveira   +5 more
doaj   +2 more sources

Vaginal Lactobacillus iners abundance is associated with outcome in antibiotic treatment of bacterial vaginosis and capable of inhibiting Gardnerella

Frontiers in Cellular and Infection Microbiology, 2022
Bacterial vaginosis is characterized as a polymicrobial dysbiosis with the loss of Lactobacillus spp. and growth of multiple anerobic bacteria, including Gardnerella, Prevotella and Atopobium ranked as the top three most abundant.
Rui Zhou, Jingjing Lu, Jingjing Lu, Jun Wang, Jun Wang, Bingbing Xiao   +5 more
doaj   +2 more sources

Biofilm-Forming Capacity and Drug Resistance of Different Gardnerella Subgroups Associated with Bacterial Vaginosis

Microorganisms, 2023
Bacterial vaginosis (BV) is the most common infection of the lower reproductive tract among women of reproductive age. Recurrent infections and antibiotic resistance associated with biofilms remain significant challenges for BV treatment.
Hanyu Qin, Yun Liu, Zhengyuan Zhai, Bingbing Xiao   +3 more
doaj   +2 more sources