Results 31 to 40 of about 2,202,696 (297)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Medicina Veterinária, 2011 Com a evolução da indústria farmacêutica, muitos medicamentos têm sido lançados e utilizados em pacientes humanos e veterinários, porém, o uso destes podem causar reações adversas, mesmo quando empregados nas doses e intervalos recomendados.
GAS Aleixo
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Medicina Veterinária, 2011 O glicosímetro é um equipamento portátil utilizado para mensurar a concentração de glicose no sangue, sendo a maioria dos aparelhos projetados para amostras de sangue capilar. Através desse estudo, objetivou-se avaliar a utilização de sangue venoso para
GAS Aleixo
doaj
Frontiers in Surgery, 2023 Spinal synovial cysts are rare entities for which standard surgical strategies are inconsistent. Here, we present an uncommon intraspinal gas-containing synovial cyst treated by percutaneous transforaminal endoscopic cystectomy.
Ziran Wei +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Religious Discourse on Gender Identity: Freedom of Expression or Hate Speech? A European Perspective
ReligionsThis paper explores the complexities arising from the intersection of religious freedom and the principles of gender equality and non-discrimination, a pressing issue within the modern European landscape.
Montserrat Gas-Aixendri
doaj +1 more source
Ler História, 2014 The Great War innovates in the production of instruments of war in a never before basis. Tactical blocking greatly influenced the Western front. Trenches, forming a completely closed system, that could only be overcome by surprise (gas and tanks) or ...
François Cochet
doaj +1 more source
A Study of Chaotic Behavior of Heat Transfer In Gas-Solid Fluidized Bed [PDF]
Engineering and Technology Journal, 2010 Fluidized beds are characterized by high heat transfer rates between thebed and internal surfaces and have uniform temperature distribution that can beachieved in fluidized bed systems. In the same time there is a chaotic behavior ofhydrodynamic and heat
e Al-Rubeai +2 more
doaj +1 more source
Eye, 1990 Two cases of subretinal gas are described. The circumstances in which this complication arose are important in understanding the mechanism by which gas gains access into the subretinal space. Evacuation of subretinal gas by posturing should be avoided as this leads to an increase in the extent of the retinal detachment and its extension anterior to ...
Ansons, AM +3 more
openaire +4 more sources