Results 51 to 60 of about 143,065 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Rotation of the polarization of light as a tool for investigating the collisional transfer of angular momentum from rotating molecules to macroscopic gas flows

Physical Review Research, 2022
We present a detailed theoretical and experimental study of the rotation of the plane of polarization of light traveling through a gas of fast-spinning molecules. This effect is similar to the polarization drag phenomenon predicted by Fermi a century ago
Ilia Tutunnikov, Uri Steinitz, Erez Gershnabel, Jean-Michel Hartmann, Alexander A. Milner, Valery Milner, Ilya Sh. Averbukh   +6 more
doaj   +1 more source

Thermally Induced Flow in Gas Centrifuge, (I) [PDF]

Journal of Nuclear Science and Technology, 1973
Centrifugally driven thermal convection near the cooled rotor conver of a centrifuge is treated. Boundary layer equations are reduced to ordinary differential equations by the Lees-Levy transformation, and solved numerically by applying the quasilinearization method. Sample solutions for radial and azimuthal velocity profiles are presented.
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Investigation the effective factors on the forces acting on the scoop in a gas centrifuge machine in three-dimensional conditions with the DSMC method [PDF]

مجله علوم و فنون هسته‌ای
This article presents a simulation of a scoop inside the rotor of a gas centrifuge machine in three dimensions. The scoop inside the centrifuge machine is 3D and curved in shape. Therefore, a 3D simulation is necessary to analyze the proper flow behavior
S. Basiri, S.J. Safdari, S.M. Ghoreshi, S. Yousefi-Nasab   +3 more
doaj   +1 more source

Continuous Centrifuge Decelerator for Polar Molecules

, 2013
Producing large samples of slow molecules from thermal-velocity ensembles is a formidable challenge. Here we employ a centrifugal force to produce a continuous molecular beam with a high flux at near-zero velocities.
Bayerl, J., Chervenkov, S., Gantner, T., Rempe, G., Rohlfes, A., Wu, X., Zeppenfeld, M.   +6 more
core   +1 more source

Waves in gas centrifuges: a review

Journal of Physics: Conference Series, 2020
Abstract Waves in gas centrifuges are generated by scoops for withdrawal of the gas. The physics of the waves and their role in the gas dynamics are under discussion. Strong centrifugal and Coriolis forces have dramatic impact on the properties and dispersion relation of the waves.
S.V. Bogovalov, V.A. Kislov, I.V. Tronin
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Analysis of Horizontal Earth Pressure Acting on Box Culverts through Centrifuge Model Test

Applied Sciences, 2022
Underground space is being utilized due to the saturation of surface ground. The box culvert, as a representative infrastructure that has moved underground, is installed to protect such fixtures as electricity and gas.
Kicheol Lee, Joonyoung Kim, Sang Inn Woo
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source