Results 201 to 210 of about 31,025 (260)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Recent studies on gas hydrates-Activities of gas hydrate studies in Japan.

Journal of the Japanese Society of Snow and Ice, 1996
openaire   +3 more sources

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics

Advanced Science, EarlyView.
This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Unsuccessful Coupling of Weakly Coordinating Anion–Based Mg Salts and Alkoxyalkylamine Solvents for Rechargeable Mg Battery Application: Trace Water‐Driven Interfacial Failure

Advanced Science, EarlyView.
Combining recently established two ground‐breaking concepts, the adoption of WCAs and the use of alkoxyalkylamine‐based solvents in electrolyte formulations for rechargeable magnesium metal batteries, has led to unexpectedly unsuccessful electrochemical Mg plating/stripping performance. Comprehensive experimental and computational analyses revealed the
Toshihiko Mandai, Antoine Barthélemy, Hendrik Koger, Harald Scherer, Ingo Krossing   +4 more
wiley   +1 more source

Interfacial Water Configurations: Evolution and Implications for Electrocatalysis

Advanced Science, EarlyView.
A comprehensive and mechanistic understanding of how interfacial water structures govern reaction pathways. This review aims to bridge the gap between unraveling the intricate role of water structures and establishing robust design principles for advanced catalysts.
Aoqi Wang, Yang Song, Lin Guo, Chenchen Weng, Yanxia Yuan, Chaoyu Li, Xue Yang, Wei Lin   +7 more
wiley   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay

Chem & Bio Engineering
Chang Chen, Yu Zhang, Xiaosen Li, Yuru Chen, Du Wang   +4 more
doaj   +1 more source