Results 331 to 340 of about 24,180 (354)

New insights into Gasdermin D pore formation.

Biochemical Society Transactions
Gasdermin D (GSDMD) is a pore-forming protein that perforates the plasma membrane (PM) during pyroptosis, a pro-inflammatory form of cell death, to induce the unconventional secretion of inflammatory cytokines and, ultimately, cell lysis.
Shirin Kappelhoff, Eleonora Margheritis, Katia Cosentino   +2 more
semanticscholar   +1 more source

Gasdermin E shields PDAC

Nature Reviews Cancer, 2022
openaire   +2 more sources

Versatility of gasdermin D beyond pyroptosis

Trends in Cell Biology
Gasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis.
Tianming Zhao, Zhexu Chi, Di Wang
openaire   +2 more sources

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

Nature
Gang Du, L. Healy, Liron David, Caitlin Walker, T. El‐Baba, Corinne A Lutomski, Byoungsook Goh, Bowen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, A. Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R. Luo, Jonathan C. Kagan, Sungwhan F. Oh, Carol V. Robinson, Judy Lieberman, Hao Wu   +22 more
semanticscholar   +1 more source

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.

TIBS -Trends in Biochemical Sciences. Regular ed, 2017
Jianjin Shi, Wenqing Gao, F. Shao
semanticscholar   +1 more source

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

International Journal of Molecular Sciences, 2021
Kohsuke Tsuchiya
exaly  

Gasdermin D-mediated metabolic crosstalk promotes tissue repair.

Nature
Zhexu Chi, Sheng Chen, Dehang Yang, Wenyu Cui, Yang Lu, Zhen Wang, Mobai Li, Weiwei Yu, Jian Zhang, Yu Jiang, Ruya Sun, Qi Yu, Tianyi Hu, Xiaoyang Lu, Qiqi Deng, Yidong Yang, Tianming Zhao, Mengfei Chang, Yuying Li, Xue Zhang, M. Shang, Q. Xiao, Kefeng Ding, Di Wang   +23 more
semanticscholar   +1 more source

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response

Nature Communications, 2022
Zhaoting Li, Quanyin Hu
exaly  

Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases.

Immunity
Kate E Lawlor, J. M. Murphy, J. Vince
semanticscholar   +1 more source

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Nature, 2020
Zhibin Zhang, Ying Zhang, Shiyu Xia
exaly