Results 71 to 80 of about 5,068 (260)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

open access: yesAdvanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li   +4 more
wiley   +1 more source

Qualitative and Quantitative Determination of Secondary Metabolites and Evaluation of Antiulcer Activity of Hydroalcoholic Extract of Buchanania lanzan Leaf Extract [PDF]

open access: yes
The most prevalent digestive condition in clinical practice is peptic ulcer. It should be regarded as a superior choice for the treatment of peptic ulcer given the numerous side effects of contemporary medicine, the initial acquisition of fewer side ...
Shrivastava, Deepa, Saksena, Surabhi
core   +2 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

open access: yesAdvanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li   +7 more
wiley   +1 more source

Дослідження шлункової секреції у щурів з ад'ювантним артритом на тлі застосування ібупрофену та його комбінації з вінбороном [PDF]

open access: yes, 2016
Гладких Ф. В., Степанюк Н. Г. Дослідження шлункової секреції у щурів з ад'ювантним артритом на тлі застосування ібупрофену та його комбінації з вінбороном. Фармакологія та лікарська токсикологія. 2016. № 3 (49). С.
Степанюк, Н.Г.   +1 more
core  

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

open access: yesAdvanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng   +7 more
wiley   +1 more source

GASTRIC ACIDITY DETERMINATION PROCEDURES [PDF]

open access: yes, 1957
Joseph S. Rechtschaffen
core   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

open access: yesAdvanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander   +14 more
wiley   +1 more source

Risk factors associated with the exposure of neonates to acinetobacters through the ingestion of infant formula in NICUs [PDF]

open access: yes, 2011
Acinetobacter is gaining importance as a pathogen in intensive care units (ICUs) due to the numerous outbreaks reported and the severity of the infections caused.
Juma, NAH
core  

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