Results 231 to 240 of about 274,852 (292)

A scalable workflow for sensitive detection and genomic profiling of tumour cells in lymph nodes from FFPE tissue

The Journal of Pathology, EarlyView.
Abstract Accurate detection of lymph node (LN) metastases is critical for prognosis and surgical decision‐making in head and neck squamous cell carcinoma (HNSCC) and other epithelial cancers. Standard histopathology examines only a small fraction of LN tissue, limiting sensitivity for micrometastases and isolated tumour cells.
Tristan Bergmann, Marianne Hölbling, Monica Sudarsanam, Christiane Driemel, Maximilian E Daniels, Joanna Swierz, Sandra Jaschinski, Maximilian Seidl, Norbert R Kübler, Wolfram T Knoefel, Rui PL Neves, Karl C Sproll, Nikolas H Stoecklein   +12 more
wiley   +1 more source

The European honey buzzard (Pernis apivorus) as an ally for the control of the invasive yellow‐legged hornet (Vespa velutina nigrithorax)

Pest Management Science, Volume 81, Issue 4, Page 2237-2247, April 2025.
The predatory effect of the honey‐buzzard affects the reproductive performance of Asian‐hornet colonies, decreasing the density of workers over distance and time. The foraging distances of the honey‐buzzard concentrates within the first 2000 m from nest, which supports the results observed.
Jorge Ángel Martín‐Ávila, Luisa María Díaz‐Aranda, José Manuel Fernández‐Pereira, Salvador Rebollo   +3 more
wiley   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

Gastric band

, 2012
openaire   +1 more source

Chaetocin Induces Ferroptosis in Cisplatin‐Resistant Ovarian Cancer Cells Through Neddylation‐Mediated TFRC Upregulation

Phytotherapy Research, EarlyView.
Chaetocin induces ferroptosis in cisplatin‐resistant ovarian cancer cells through neddylation‐mediated TFRC upregulation. ABSTRACT Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure.
Hanfei Xie, Wumin Dai, Lu Sun, Wangang Gong, Tao Zhu, Yingli Zhang   +5 more
wiley   +1 more source

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

Phytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen, Xin Dong, Haowen Zhuang, Yusheng Huang, Mengyuan Wang, Zhongzheng Zhang, Jinhong Chen, Wei Wang, Chun Li, Junyan Wang   +9 more
wiley   +1 more source

Identification of Active Compounds of Centipeda minima for Potentiating Tumor Immunotherapy in Non‐Small Cell Lung Cancer via FANCD2‐cGAS/STING/IFN‐I Signaling Axis

Phytotherapy Research, EarlyView.
Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang, Chu‐Ying Chen, Jiang‐Tao Xiao, Rou‐Qiao Zheng, Wen‐Da He, Zi‐Wei Xu, Su‐Fen Wei, Tao Su, Guang‐Biao Zhou, Yong‐Qiang Liu   +9 more
wiley   +1 more source

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source

Endoscopic Versus Surgical Bariatric Interventions for Obesity: A Systematic Review and Network Meta-Analysis. [PDF]

J Clin Med Res
Abdelmoaty M, Muhanna AMA, Attia RMM, Ibrahim AA, Alqahtani SS, Aseeri HS, Alqahtani RS, Jamal B, Alshehri M, Alkasi AM, Ogran NA, Barakat KEE, Metwaly ASA.   +12 more
europepmc   +1 more source