Results 191 to 200 of about 43,226 (268)

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 762-773, September 2026.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat, Haribhau Kangne, Rasmus Jansson‐Löfmark, Jens K. Hertel, Amin Rostami‐Hodjegan, Ida Robertsen, Aleksandra Galetin   +6 more
wiley   +1 more source

Complication imaging after laparoscopic Roux-en-Y gastric bypass: clues to the diagnosis and pitfalls. [PDF]

Insights Imaging
Gebauer C, Kopf H, Kulinna-Cosentini C, Tentschert G, Schima R, Klaus A, Schima W.   +6 more
europepmc   +1 more source

Combination Pharmacotherapies for Obesity—Current Evidence and Future Directions

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Combination pharmacotherapy for obesity can enhance weight loss by targeting complementary neuroendocrine and metabolic pathways. Such benefits are largely additive but limited by tolerability, cost and access. This review outlines practical clinical archetypes and a research agenda for safer, more precise and durable combination strategies across ...
A. B. M. Kamrul‐Hasan, Arnav Kalra, Nitin Kapoor, Deep Dutta, Kunal Mahajan, Robin Maskey, Syed Abbas Raza   +6 more
wiley   +1 more source

Recurrent Jejunojejunal Intussusception of the Common Limb in a Patient With Roux-en-Y Gastric Bypass: A Report of an Unusual Case and Literature Review. [PDF]

Cureus
Navalón Calzada A, Chavéz Cadena OG, Reyes Rementeria B, Turrent Pinedo R.   +3 more
europepmc   +1 more source

Glucose and Loss of Control Eating: Evidence From Naturalistic Assessment After Roux‐en‐Y Gastric Bypass

European Eating Disorders Review, Volume 34, Issue 5, Page 1304-1313, September 2026.
ABSTRACT Objective While loss of control (LOC) eating is associated with poor outcomes following metabolic and bariatric surgery (MBS), the mechanisms driving it are less understood. This study used momentary, naturalistic data to examine glucose as a biological correlate of LOC eating after Roux‐en‐Y gastric bypass (RYGB).
Gail A. Kerver, Kristine J. Steffen, Debra L. Safer, Glen Forester, David B. Sarwer, Stephen A. Wonderlich, Scott G. Engel   +6 more
wiley   +1 more source

Symptomatic Chronic Strongyloides Stercoralis Infection after Roux-en-Y Gastric Bypass in an Immunocompetent Patient. [PDF]

Eur J Case Rep Intern Med
Stevens J, van Meer MPA, Roerink SHPP, Gisolf JH, Ooft ML, Vrolijk JM, Hassing RJ.   +6 more
europepmc   +1 more source

Postoperative Effects of Celecoxib on Opioid Use and Pain Control After Benign Oropharyngeal Surgery

The Laryngoscope, Volume 136, Issue 9, Page 4072-4080, September 2026.
This study evaluated how the addition of celecoxib to a multimodal pain regimen following tonsillectomy + adenoidectomy, or uvulopalatopharyngoplasty (UPPP) + tonsillectomy affects postoperative opioid use and pain control. Patients who received celecoxib consumed significantly fewer opioids compared to the historic control group, with similar ...
Alana Platukus, Praneet Kaki, Anastasia Kaffenes, Udeerna Tippabhatla, Jared Robinson, Jaehee Kim, Erin Creighton, Meghan Crippen, Maurits Boon, Colin Huntley   +9 more
wiley   +1 more source

Robotic versus laparoscopic Roux-en-Y gastric bypass: a propensity-matched comparison of the inflammatory response and MASLD trajectories. [PDF]

J Robot Surg
Tuffs C, Delistamatis M, Hauenschild A, Sauerbier L, Amin D, Kosovic A, Amati AL, Albrecht JU, Askevold I, Sprenger T, Schneider M, Strowitzki MJ.   +11 more
europepmc   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Concurrent stricturoplasty with lumen-apposing metal stents for gastrojejunal strictures after Roux-en-Y gastric bypass. [PDF]

Surg Endosc
Zhu X, Mocanu V, Kachornvitaya P, Wills MV, Strong A, Navarrete S, Lee Y, Barajas-Gamboa JS, Corcelles R, Dang J, Kroh M.   +10 more
europepmc   +1 more source