Results 301 to 310 of about 924,361 (397)

Hospital variation in treatment for synchronous metastatic esophageal and gastric cancer: A nationwide population‐based study in the Netherlands

open access: yesInternational Journal of Cancer, Volume 157, Issue 7, Page 1446-1457, 1 October 2025.
What's New? A range of treatment options exist for metastatic esophageal (EC) and gastric cancer (GC). Which modalities or combination thereof are optimal for these malignancies, however, remains uncertain. Here, the authors examined differences in systemic treatment for metastatic EC and GC across hospitals in the Netherlands.
Julie F. M. Geerts   +11 more
wiley   +1 more source

GLP-1 and GIP may play a role in long-term weight trajectories after gastric bypass. [PDF]

open access: yesFront Endocrinol (Lausanne)
Andrade S   +9 more
europepmc   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 19, Page 4490-4515, October 2025.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

A cost‐effectiveness analysis of behavioural, pharmacological, and surgical obesity treatments in Canada

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5748-5760, October 2025.
Abstract Aims Effective weight management pharmacotherapies are a new alternative to bariatric surgery or health behaviour intervention (HBI) alone. Comparative cost‐effectiveness evaluations can guide decision‐making. We aimed to evaluate the cost‐effectiveness of sleeve gastrectomy (SG), Roux‐en‐Y gastric bypass (RYGB), semaglutide, tirzepatide, and ...
Nisha Gupta   +5 more
wiley   +1 more source

Higher plasma dicarbonyl levels are associated with liver fibrosis in obese individuals

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5878-5888, October 2025.
Abstract Introduction Methylglyoxal (MGO) is a very reactive compound that modifies proteins, forming advanced glycation end products (AGEs) and activating inflammatory pathways. Elevated MGO levels have been linked to various diseases, including type 2 diabetes and atherosclerosis. However, the role of MGO and other glycating agents in the progression
Oluwatomisono I. Akinrimisi   +12 more
wiley   +1 more source

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