Results 141 to 150 of about 3,763,730 (308)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

D2 Lymph Node Dissections during Reduced-port Robotic Distal Subtotal a Gastrectomy and Conventional Laparoscopic Surgery Performed by a Single Surgeon in a High-volume Center: a Propensity Score-matched Analysis

, 2020
Purpose: Various studies have indicated that reduced-port robotic gastrectomies are safe and feasible for treating patients with early gastric cancer.
손태일, 이세진, 형우진, 최서희, 김유민, 송정호, 김형일, 조민아, Seohee Choi, Woo Jin Hyung, Taeil Son, Jeong Ho Song, Sejin Lee, Yoo Min Kim, Minah Cho, Hyoung-Il Kim   +15 more
core   +1 more source

A modified liver retraction method decreases liver dysfunction after laparoscopic gastrectomy

World Journal of Surgical Oncology
Background In laparoscopic gastrectomy, liver retraction is an important procedure to obtain a sufficient operative view to ensure the quality of surgery. However, postoperative liver dysfunction is frequently encountered after liver retraction.
Hao-Jie Li, Lang Zhou, Wei-Han Zhang, Kai Liu, Kun Yang, Jian-Kun Hu, Xiao-Long Chen   +6 more
doaj   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Case-Control Study of Dietary Pattern and Other Risk Factors for Gastric Cancer [PDF]

The rates of gastric cancer reported from Ardabil Province of Iran, are among the highest in the world. The aim of this study was to investigate the risk factors for gastric cancer in Ardabil Province.
نعمتی, علی, مهدوی, رضا, نقی زاده باقی, عباس   +2 more
core  

Helicobacter pylori and gastric cancer: mechanisms and new perspectives

Journal of Hematology & Oncology
Gastric cancer remains a significant global health challenge, with Helicobacter pylori (H. pylori) recognized as a major etiological agent, affecting an estimated 50% of the world’s population.
Yantao Duan, Yonghu Xu, Yi Dou, Dazhi Xu
doaj   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Helicobacter pylori infection appears essential for stomach carcinogenesis: Observations in Semarang, Indonesia [PDF]

, 2005
The gastric cancer incidence in Semarang, Indonesia, is exceedingly low: only approximately 1/100th of the level in Japan. To elucidate the reason, we carried out an ecological study recruiting 69 male and 102 female participants from the general ...
Wijaya, Indra, Miranti, Ika P., Moore, Malcolm A., Triono, Teguh, Soeripto, Soeripto, Ghadimi, Reza, Hosono, Akihiro, Samsuria, Witjitra D., Tokudome, Shinkan, Triningsih, F. X. Ediati, Suzuki, Sadao, Sarjadi, Sarjadi   +11 more
core  

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Gastric Cardia Cancer; The Most Common Type of Upper Gastrointestinal Cancer in Ardabil, Iran: An Endoscopy Clinic experience [PDF]

Background-According to a recent report published by the Ministry of Health and Medical Education of the I. R. of Iran, gastric cancer (GC) is the most common fatal cancer in this country and its prevalence is highest in Ardabil province, Northwest of ...
درخشان, محمدحسین, ملک زاده, رضا, عرشی, شهنام, سجادی, علیرضا, یزدانبد, عباس   +4 more
core