Results 91 to 100 of about 137,793 (312)

Reduced NGF in Gastric Endothelial Cells Is One of the Main Causes of Impaired Angiogenesis in Aging Gastric MucosaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Aging gastric mucosa has increased susceptibility to injury and delayed healing owing to impaired angiogenesis, but the mechanisms are not fully known. We examined whether impairment of angiogenesis in aging gastric mucosa is caused by
Amrita Ahluwalia, Michael K. Jones, Neil Hoa, Ercheng Zhu, Tomasz Brzozowski, Andrzej S. Tarnawski   +5 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Macroscopical appearance of the gastric mucosa in rats.

, 2012
The negative control group (A) has no injury of gastric mucosa. The ulcer control group (B) shows sever injuries in the gastric mucosa. Absolute ethanol produced extensive visible hemorrhagic necrosis of gastric mucosa.
Maryam Hajrezaie (112763), A. Hamid A. Hadi (112781), Nazia Majid (112788), Mahmood Ameen Abdulla (112793), Pouya Hassandarvish (112772), Shahram Golbabapour (112768), Nura Suleiman Gwaram (112777), Hapipah Mohd Ali (112784)   +7 more
core   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Ectopic cutaneous umbilical gastric mucosa

, 2016
A 2‑year‑old male child presented with a complaint of bleeding from umbilicus every 15 days since birth on and off. Child was managed successfully by exploratory laparotomy and local umbilectomy.
Lal, Shubha, Rattan, Kamal Nain, Sonika, Pallavi, Rattan, Ananta   +3 more
core   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Prostaglandin cytoprotection of gastric mucosa

Gastroenterology, 1978
Abstract The mechanisms by which prostaglandins protect the gastric mucosa against the erosive action of ulcerogenic drugs, such as indomethacin, is unknown. The hypothesis was tested that topical damaging agents inhibit the active transport of sodium in the gastric mucosa and that a cytoprotective prostaglandin will reverse this effect.
T K, Chaudhury, E D, Jacobson
openaire   +2 more sources

Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2 0-deoxyguanosine, in rat colonic mucosa [PDF]

, 1998
Dextran sodium sulfate (DSS) given in drinking water can induce colonic Inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic.
Petit, Claude, Embvani, E., Jaeg, Jean-Philippe, Tardieu, Didier, Corpet, Denis E., Cadet, Jean   +5 more
core  

Macroscopic appearance of the gastric mucosa in rats.

, 2013
The negative control group showed no injuries to the gastric mucosa (A). Severe injuries were observed in the gastric mucosa of the ethanol control group. Ethanol treatment produced extensive visible hemorrhagic lesion of the gastric mucosa (B).
A. Hamid A. Hadi (112781), Maryam Hajrezaie (112763), Mahmood A. Abdulla (388944), Pouya Hassandarvish (112772), Kamal A. Ketuly (388942), Shahram Golbabapour (112768), Hapipah Mohd Ali (112784), Nazia Abdul Majid (388943)   +7 more
core   +1 more source