A recombinant AAV delivered tumour gene therapy. NF‐κB drives tumour‐selective antigen (e.g., CD20) expression. Ectopic CD20 enables rituximab repurposing to solid tumours. ADCC, ADCP, and CDC contribute to the antitumour activity. Abstract Background Despite the clinical success of cancer immunotherapies, their efficacy is often compromised by antigen‐
Ziyan Kong +6 more
wiley +1 more source
The clinical effects of laparoscopic gastrojejunostomy versus nasointestinal tube insertion with subsequent chemotherapy for uncurable gastric cancer patients with outlet obstruction. [PDF]
Ruan Z, Yang C, Lin S, Li W.
europepmc +1 more source
Dietary partitioning mediates species coexistence in the high seas area of northwest Pacific
Niche partitioning, manifesting along various axes of the ecological niche, is a fundamental mechanism mediating species coexistence in a system. However, the emergence of many species in marine ecosystems would face considerable constraints in achieving coexistence through spatiotemporal differentiation mechanisms under the framework of niche ...
Na Zang +6 more
wiley +1 more source
Surgical Surprise and a Ryle's Tube Misadventure: An Intraoperative Gastric Perforation. [PDF]
Koripella S +4 more
europepmc +1 more source
Clinical evaluation of the i-gel Plus supraglottic airway in Japanese patients: A prospective observational study. [PDF]
Nakanishi T +8 more
europepmc +1 more source
Abstract Assigning taxonomic identity and thus assessing taxonomic diversity in gelatinous zooplankton is challenging due to their fragility and difficult preservation. Formalin fixation compromises DNA integrity, while flash‐freezing, ethanol, and acetone preservation affect morphological features. In this study, we developed a methodological protocol
Claudia Traboni +4 more
wiley +1 more source
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen +3 more
wiley +1 more source
Accuracy of Bedside Methods for Preliminary Nasoenteric Tube Tip Localization in Intensive Care: A Prospective Diagnostic Study. [PDF]
Yu Q +5 more
europepmc +1 more source
The new species Barleria kulalensis I.Darbysh. & Q.Luke and Dicliptera huriensis I.Darbysh. & Q.Luke are described and illustrated and their extinction risk is assessed provisionally. The former is based on Barleria sp. G of the Flora of Tropical East Africa (FTEA), with recent field observation and collection of this species from the foothills of ...
Iain Darbyshire, Quentin Luke
wiley +1 more source
Anesthetic management of a gross type C tracheoesophageal fistula by balloon catheter via tracheostoma in an infant with trisomy 18: A Case Report. [PDF]
Ryo M +4 more
europepmc +1 more source

