Results 321 to 330 of about 140,907 (385)

Progress on the development of Class A GPCR‐biased ligands

open access: yesBritish Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales   +20 more
wiley   +1 more source

Colon‐targeted complement C5a1 receptor inhibition using pH‐sensitive nanoparticles ameliorates experimental colitis

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The complement system is associated with inflammatory bowel disease (IBD) pathology. Complement activation induces C5a production, which signals through the C5a1 receptor (C5aR1) to drive inflammatory responses that may underlie IBD.
Cedric S. Cui   +11 more
wiley   +1 more source

Predictors of Mortality in Patients With Multiple Endocrine Neoplasia Type 1

open access: yesClinical Endocrinology, EarlyView.
SUMMARY Objective Multiple Endocrine Neoplasia Type 1 (MEN 1) is an autosomal dominant disease predisposing to hyperplasia and neoplasia in diverse endocrine tissues. Patients typically present with endocrine abnormalities before the age of 30 years and have reduced life expectancy.
Jasmine J. Zhu, John R Burgess
wiley   +1 more source

Vouwo mud dye: A material, microbiological and cultural approach to researching sustainable textile dyes

open access: yesColoration Technology, EarlyView.
Abstract Coloration using soil‐based dyes is a fast‐growing subject of enquiry in fibres and textile surface design, with pigments and microbes involved in their production being extensively researched. Dyeing techniques using this rich natural resource have also been integral to long‐standing textile traditions worldwide.
Laurence Douny   +6 more
wiley   +1 more source

Ectopic bile duct concomitant with gastric ulcer hemorrhage: report of a case. [PDF]

open access: yesSurg Case Rep
Nagasawa Y   +4 more
europepmc   +1 more source

Stroke‐Homing Peptide‐DNase1 Alleviates Intestinal Ischemia Reperfusion Injury by Selectively Degrading Neutrophil Extracellular Traps

open access: yesCell Proliferation, EarlyView.
SHp‐DNase1 combined with CRO inhibits NETs to alleviate intestinal IRI ABSTRACT Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI).
Tingting Liu   +12 more
wiley   +1 more source

Deciphering the Immunomodulatory Function of GSN+ Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics Analysis

open access: yesCell Proliferation, EarlyView.
Pan‐cancer scRNA‐seq and ST‐seq analyses identify GSN+ inflammatory cancer‐associated fibroblasts (CAFs) and their spatial distribution in immune checkpoint inhibitor (ICI) therapy. The Caf.Sig model accurately predicts ICI response across cancers using CAF gene signatures and machine learning.
Shan Li   +18 more
wiley   +1 more source

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