Results 221 to 230 of about 1,469,315 (256)

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Ligation-assisted endoscopic mucosal resection versus endoscopic submucosal dissection for small gastrointestinal deep-layer lesions: A retrospective cohort study. [PDF]

J Int Med Res
Zhang Q, Zhou Y, Pan P, Hu H, Xiao Z, Liu R, Zhang D, Tang A, Deng M, Wang X, Li J, Wang W.   +11 more
europepmc   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Validation of Claims-Based Algorithms for Identifying Congenital Urinary Tract, Genital, Gastrointestinal, and Musculoskeletal Malformations. [PDF]

Pharmacoepidemiol Drug Saf
Fung K, Leonard SA, Huybrechts KF, Hernandez-Diaz S, Bateman BT, Straub L, Sujan A, Gray KJ, Andersen K, Chen EY, El-Tayeb K, Jeancharles M, Mootz AA, Winkler AE, Fernando AM, Qin CX, Stockert EW, Mogun H, Zhu Y.   +18 more
europepmc   +1 more source

Precision Sedation for Gastrointestinal Endoscopy in Older Adults: Brain Vulnerability and Recovery. [PDF]

Drug Des Devel Ther
Qian H, Gu H, Zhu J, Chen K, Jiang P, Zheng L.   +5 more
europepmc   +1 more source

Increased Polymicrobial Infection Rates and Associated Mortality in Patients With Chronic Gastrointestinal Disease Undergoing Antibiotic Spacer Placement for Periprosthetic Joint Infection. [PDF]

Arthroplast Today
Wier J, Telang SS, Kumaran P, Iyer A, Lieberman JR, Heckmann ND.   +5 more
europepmc   +1 more source

Gastrointestinal symptoms and association to food items in children with hirschsprung disease: a multinational patient-reported outcome study from Latin America and Spain. [PDF]

Pediatr Surg Int
Scaramella C, Telborn L, Davidson J, Day H, de Andres Crespo M, Busoni V, Lobos P, Lindert J.   +7 more
europepmc   +1 more source