Results 251 to 260 of about 10,588,678 (413)

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Long-term exposure to air pollution and gastrointestinal disease: findings from a nationwide cohort study in China. [PDF]

BMC Public Health
Kou Y, Ye S, Du W, Lu Z, Yang K, Zhan L, Huang Y, Qin L, Yang Y.   +8 more
europepmc   +1 more source

Association Between Migraine and Gastrointestinal Disease in Pediatric Patients: A Propensity Score Weighting Approach. [PDF]

Neuropsychiatr Dis Treat, 2023
Rhew K.
europepmc   +1 more source

DELAYED ONSET OF GASTROINTESTINAL DISEASE IN THE RECIPIENTS OF BONE MARROW TRANSPLANTS

, 1982
Fredric T. Serota, Henrietta Kotlus Rosenberg, James A. Rosen, P. Koch, Charles S. August   +4 more
openalex   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström's Macroglobulinemia in Remission: An Unusual Report with Review. [PDF]

Int J Hematol Oncol Stem Cell Res
Jitani A, Mundhe MB, Husain KW, Menghani H, Desai M, Nair V.   +5 more
europepmc   +1 more source

Serum vitamin D status in a cohort of infants with food protein‑induced gastrointestinal disease. [PDF]

Biomed Rep, 2023
Zhou MY, Li X, Yang J, Xiong LJ, He XQ, He XQ, Xie XL.   +6 more
europepmc   +1 more source

Practical diagnosis: Gastrointestinal and liver disease

, 1980
John G. Banwell, Julian V. Deese
openalex   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Association of systemic inflammatory response index with all-cause and malignant neoplasm mortality in patients with gastrointestinal disease. [PDF]

Transl Cancer Res
Wang P, Zhu H, Jiang S, Liu X, Gao B, Bai W, Xie W, Shao G.   +7 more
europepmc   +1 more source