Results 321 to 330 of about 10,995,900 (379)

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Family History of Eosinophilic Esophagitis or Other Eosinophilic Gastrointestinal Disease Is Not Associated With Response to Topical Steroids in Eosinophilic Esophagitis. [PDF]

Gastro Hep Adv
Xue AZ, LaFata SS, Gee TS, Thel HL, Cameron BA, Kiran A, Ocampo AA, McCallen J, Lee CJ, Borinsky SA, Redd WD, Barlowe TS, Kaakati RN, Cotton CC, Eluri S, Reed CC, Dellon ES.   +16 more
europepmc   +1 more source

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Co-occurrence of collagenous gastrointestinal disease in siblings in early childhood: New insight into a rare condition. [PDF]

JPGN Rep
Luitingh TL, Ng J, McGrath KH.
europepmc   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

Advanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang, Yirong An, Shiran Tao, Shenao Qu, Minge Wu, Guantong Fang, Ziqing Chen, Weilun Song, Haoze Leng, Rongqian Wu, Yi Lyu, Xiaoli Liu, Dinghui Dong   +12 more
wiley   +1 more source

Molecular characterization and lineage analysis of canine astrovirus strains from dogs with gastrointestinal disease in Ecuador based on ORF-2 gene analysis. [PDF]

Front Vet Sci
Loor-Giler A, Santander-Parra S, Castillo-Reyes S, Campos M, Mena-Perez R, Prado-Chiriboga S, Nunez L.   +6 more
europepmc   +1 more source

The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies. [PDF]

Prev Nutr Food Sci
Moludi J, Saber A, Zozani MA, Moradi S, Azamian Y, Hajiahmadi S, Pasdar Y, Moradi F.   +7 more
europepmc   +1 more source

The effects of dairy on the gut microbiome and symptoms in gastrointestinal disease cohorts: a systematic review. [PDF]

Gut Microbiome (Camb)
Ní Chonnacháin C, Feeney EL, Gollogly C, Shields DC, Loscher CE, Cotter PD, Noronha N, Stack R, Doherty GA, Gibney ER.   +9 more
europepmc   +1 more source

Effect of oral or subcutaneous administration of cyanocobalamin in hypocobalaminemic cats with chronic gastrointestinal disease or exocrine pancreatic insufficiency. [PDF]

J Vet Intern Med
Chang CH, Lidbury J, Suchodolski JS, Steiner JM.   +3 more
europepmc   +1 more source