Results 341 to 350 of about 10,655,093 (390)

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo   +7 more
wiley   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao   +20 more
wiley   +1 more source

Sevelamer-Induced Gastrointestinal Disease in 12 Patients with End-Stage Renal Disease: A Case Series. [PDF]

open access: yesClin Transl Gastroenterol
Todd J   +5 more
europepmc   +1 more source

Malnutrition and gastrointestinal disease

Current Opinion in Gastroenterology, 2002
The recognition of several disease processes that cause or are associated with gastrointestinal malabsorption has led to extensive investigation into their pathogenesis, diagnosis, and treatment. This review of selected articles covers a range of subjects related to some of the more common malabsorptive disease. Selected topics including celiac disease,
Darren A. Kastin, Alan L. Buchman
openaire   +4 more sources

Epidemiology of Gastrointestinal Disease [PDF]

open access: possible, 2012
The elderly represent a unique cohort of the US population—and their numbers are on the rise. Among the medical community, being 65 years or older represents an age associated with multiple comorbid conditions and a point in life at which practitioners are typically less likely to advise aggressive diagnostic, medical, and surgical interventions for ...
Dhiraj Yadav   +2 more
openaire   +2 more sources

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