Results 51 to 60 of about 1,253,420 (339)

Poor Outcome in a Mitochondrial Neurogastrointestinal Encephalomyopathy Patient with a Novel TYMP Mutation: The Need for Early Diagnosis. [PDF]

, 2012
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and ...
Bax, BE, Bereczki, C, Buono, R, Filosto, M, Padovani, A, Russignan, A, Scarpelli, M, Tonin, P, Zappini, F, Zombor, M   +9 more
core   +3 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

Nature Communications, 2019
The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of ...
Yun Zhao, Rachid Zagani, Sung-Moo Park, Naohiro Yoshida, Pankaj Shah, Hans-Christian Reinecker   +5 more
doaj   +1 more source

Epidemiological trends of notified human brucellosis in Germany, 2006–2018

International Journal of Infectious Diseases, 2020
Objective: We describe epidemiological trends of human brucellosis in Germany over a 13 year period based on national surveillance data. Methods: We analyzed demographic, clinical, laboratory and exposure information of symptomatic laboratory-confirmed ...
Julia Enkelmann, Klaus Stark, Mirko Faber   +2 more
doaj   +1 more source

Gastrointestinal Diseases of the Ferret

Veterinary Clinics of North America: Exotic Animal Practice, 2005
Gastrointestinal (GI) disease is common in pet ferrets. According to Delaney, unique ferret anatomy and physiology, including rapid GI transit time, and short, simple GI tract predisposes to GI disease [1]. Etiologies include bacteria, including helicobacter infections, virus, parasites, inflammatory conditions, neoplasia, foreign body-related diseases,
openaire   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Exploring the Association between Elevated Liver Enzymes and Diabetes in the PERSIAN Guilan Cohort Study [PDF]

Caspian Journal of Internal Medicine
Background: Diabetes mellitus (DM) is highly consequential to global health among chronic diseases. Due to a limited researches that have examined relationships between liver enzymes and DM, this study aimed to investigate the link between elevated liver
Mohammad Taghi Ashoobi, Farahnaz Joukar, Kourosh Mojtahedi, Saman Maroufizadeh, Mohammadreza Javid, Ali Parvaneh, Tahereh Zeinali, Niloofar Faraji, Mohammadreza Naghipour, Fariborz Mansour-Ghanaei   +9 more
doaj  

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source