Results 51 to 60 of about 692,603 (317)

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

open access: yesMolecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger   +2 more
wiley   +1 more source

Physical activity and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study [PDF]

open access: yesCaspian Journal of Internal Medicine
Background: Regular physical activity promotes health that can affect liver health, particularly modulating liver enzymes. The objective of this study was to assess the association between physical activities and elevated liver enzyme levels in the ...
Heydar Ali Balou   +5 more
doaj  

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

open access: yesMolecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Osteoporosis in Gastrointestinal Diseases

open access: yesAdvances in Clinical and Experimental Medicine, 2015
Secondary osteoporosis occurs as an isolated pathology or co-exists with types I and II osteoporosis. The gastroenterologist may come across osteoporosis or osteopenia in a patient with a gastrointestinal disease. This is often a young patient in whom investigations should be carried out and appropriate treatment initiated, aimed at preventing bone ...
Liliana Łykowska-Szuber   +4 more
openaire   +3 more sources

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

open access: yesFEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He   +5 more
wiley   +1 more source

Upper Gastrointestinal Disease in Nairobi and Nakuru Counties, Kenya; A Two YearComparative Endoscopy Study

open access: yesThe Annals of African Surgery, 2014
Introduction: Upper gastrointestinal (UGI) complaints are a common presentation in many outpatient clinics. St Mary’s Mission Hospitals run two endoscopy units in Nairobi and Nakuru.
Makanga W, Nyaoncha A
doaj  

The global stress response regulator oxyS in an adherent-invasive Escherichia coli strain attenuates experimental colitis

open access: yesGut Microbes
Crohn’s disease and ulcerative colitis in humans and experimental immune-mediated colitis in mice are likely due in part to overactive immune responses to resident intestinal bacteria, including certain strains of adherent-invasive Escherichia coli (E ...
Diana Arsene   +2 more
doaj   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

Effects of simultaneous multislice acceleration on the stability of radiomics features in parametric maps of IVIM and DKI in uterine cervical cancer

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The aim of this study was to investigate the influence of the simultaneous multislice acceleration (SMS) technique as well as two‐dimensional (2D) and three‐dimensional (3D) tumor segmentations on radiomics features (RFs) within the parametric maps of cervical cancer, which were computed by intravoxel incoherent motion (IVIM) and ...
Shuangquan Ai   +6 more
wiley   +1 more source

Systemic EBV T-Cell Lymphoproliferative Disease of Young Adults

open access: yesActa Medica Iranica, 2014
T/NK cell proliferative EBV associated disease is a rare one which is more common in eastern Asian countries. EBV is originally associated with B cells, and EBV associated T cell lymphoma is so rare.
Zahedin Kheyri   +4 more
doaj  

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