Results 61 to 70 of about 10,995,900 (379)
Frontiers in Pharmacology, 2021 Despite structural similarity, the five subtypes comprising the cholinergic muscarinic family of G protein-coupled receptors regulate remarkably diverse biological functions.
Mazen Tolaymat +9 more
doaj +1 more source
Effects of growth factors and receptor blockade on gastrointestinal cancer [PDF]
, 2004 The advent of recombinant peptide technology offers the potential to use one or several peptides to treat a variety of gastrointestinal conditions. However, although cell culture and animal models have shown proof of concept, we are still at a relatively
Ghosh, S, Playford, RJ, Wassan, H
core +2 more sources
Duodenal carcinoid tumour – a case report [PDF]
, 2020 Duodenal carcinoids are rare tumours of the small intestine with heterogenous clinical and pathological characteristics. The long-term prognosis is very good if discovered in the early stages.
Alexescu, Teodora Gabriela +7 more
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Is the Oral Microbiome Important in HIV-Associated Inflammation? [PDF]
, 2020 Alterations in the gut microbiome during HIV infection have been implicated in chronic inflammation, but the role of the oral microbiome in this process is less clear. The article by M. K. Annavajhala, S. D. Khan, S. B. Sullivan, J. Shah, et al. (mSphere
Fulcher, Jennifer A
core +1 more source
BMC Medicine, 2018 BackgroundRotavirus causes severe gastroenteritis in infants and young children worldwide. The UK introduced the monovalent rotavirus vaccine (Rotarix®) in July 2013. Vaccination is free of charge to parents, with two doses delivered at 8 and 12 weeks of
D. Hungerford +5 more
semanticscholar +1 more source
JAMA Network Open, 2020 Key Points Question What are the incidence rates of gastrointestinal symptoms among patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection?
S. Parasa +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
JADA Foundational Science, 2022 Background: Proton pump inhibitors (PPIs), such as omeprazole, esomeprazole, and pantoprazole, are frequently prescribed to treat acid-related gastrointestinal diseases.
Paul A. Herrmann, DDS +2 more
doaj +1 more source
Noninvasive ¹³C-octanoic acid breath test shows delayed gastric emptying in patients with amyotrophic lateral sclerosis [PDF]
, 1999 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor neurons. However, ALS has been recognized to also involve non-motor systems.
Folwaczny, Christian +6 more
core +1 more source