Results 191 to 200 of about 381,169 (287)
Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction
A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod+9 more
wiley +1 more source
Recent Advances in mRNA Delivery Systems for Cancer Therapy
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang+9 more
wiley +1 more source
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang+9 more
wiley +1 more source
Gastrointestinal Disease in the Hemolytic-Uremic Syndrome
Peter F. Whitington+2 more
openalex +1 more source
Nutrition in Gastrointestinal Disease [PDF]
openaire +3 more sources
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li+11 more
wiley +1 more source
Iron deficiency anaemia in patients with rheumatic disease receiving non-steroidal anti-inflammatory drugs: the role of upper gastrointestinal lesions. [PDF]
Rajesh Upadhyay+4 more
openalex +1 more source
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen+8 more
wiley +1 more source
Assessment of Functional Gastrointestinal Disease: The Bowel Disease Questionnaire [PDF]
N. J. Talley+4 more
openalex +1 more source