Results 291 to 300 of about 10,601,238 (387)

Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases. [PDF]

J Clin Med
Severo JS, Silva ACAD, Santos BLBD, Reinaldo TS, Oliveira AM, Lima RSP, Torres-Leal FL, Santos AAD, Silva MTBD.   +8 more
europepmc   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Causal Relationship Between Cataracts and Gastrointestinal Diseases: A Two-Sample Mendelian Randomization Study. [PDF]

Transl Vis Sci Technol
Li Y, Pan QM, Wang M, Zhao B.
europepmc   +1 more source

Autoimmune diseases and risk of gastrointestinal cancer: an umbrella review of meta-analyses of observational studies

Xiao Bai, Yunran Guo, Xin-Mao Zhu, Dong‐Qiu Dai   +3 more
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Trends in Endoscopist Reporting Rates of Eosinophilic Gastrointestinal Diseases in Japan Evaluated by the Japan Endoscopy Database Project. [PDF]

DEN Open
Miyaguchi K, Tsuzuki Y, Shiotani A, Tanaka K, Imaeda H.   +4 more
europepmc   +1 more source

Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases.

Current Medicinal Chemistry, 2017
Mei Shang, Jun Sun
semanticscholar   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Application of aggregation-induced emission materials in gastrointestinal diseases. [PDF]

World J Gastroenterol
Li YR, Wang G, He WT, Liu T.
europepmc   +1 more source

Role of Ayurvedic Concept of Aahar Vidhi Visheshayatana as Preventive Aspect for Gastrointestinal Diseases.

G Mutkule, P. Deshpande, M.S. Dawre
openalex   +1 more source